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CAS No 1188-38-1 , (2S)-2-(carbamoylamino)pentanedioic acid

  • Name: (2S)-2-(carbamoylamino)pentanedioic acid
  • Synonyms: Carbaglu; Ureidoglutaric acid; Carbamylglutamic acid;(2S)-2-(carbamoylamino)pentanedioic acid; N-Carbamyl-L-glutamate; Carglumic acid; (S)-2-ureidopentanedioic acid;
  • CAS Registry Number:
  • Density: 1.499g/cm3
  • Refractive index: 1.544
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 190.154
  • InchiKey: LCQLHJZYVOQKHU-VKHMYHEASA-N
  • InChI: InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,
    11,12)(H3,7,8,13)/t3-/m0/s1
  • Risk Statements: S26;S36/37
  • Molecular Formula: C6H10N2O5
  • Molecular Structure:CAS No:1188-38-1 (2S)-2-(carbamoylamino)pentanedioic acid

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References of (2S)-2-(carbamoylamino)pentanedioic acid
Title: Carglumic acid
CAS Registry Number: 1188-38-1
CAS Name: N-(Aminocarbonyl)-L-glutamic acid
Synonyms: carbamylglutamic acid; N-carbamoyl-L-glutamic acid; l-uramidoglutaric acid; ureidoglutaric acid
Trademarks: Carbaglu (Orphan Europe)
Molecular Formula: C6H10N2O5
Molecular Weight: 190.15
Percent Composition: C 37.90%, H 5.30%, N 14.73%, O 42.07%
Literature References: Metabolically stable analog of N-acetylglutamate, a physiological activator of the first enzyme of the urea cycle, carbamylphosphate synthetase (CAPS). Prepn: H. McIlwain, Biochem. J. 33, 1942 (1939). Effect on blood urea and ammonia levels and potential clinical application: J.-E. O'Connor et al., Eur. J. Pediatr. 143, 196 (1985). Evaluation in treatment of CAPS deficiency: G. Kuchler et al., J. Inher. Metab. Dis. 19, 220 (1996); of N-acetylglutamate synthetase (NAGS) deficiency: B. Plecko et al., Eur. J. Pediatr. 157, 996 (1998).
Properties: mp 174°.
Melting point: mp 174°
Therap-Cat: In treatment of inherited urea cycle disorders.