Home > Name List By b > Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'...

CAS No 120685-11-2 , Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-

  • Name: Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
  • Synonyms: PKC 412;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonine,benzamide deriv.;N-Benzoylstaurosporine; CGP 41251;Benzamide,N-(2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-,[9S-(9a,10b,11b,13a)]-; CGP 41231; Benzoylstaurosporine;Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-; Midostaurin;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.46g/cm3
  • Refractive index: 1.76
  • Safety Statements: Hazard Codes T
  • Hazard Symbols: T: Toxic;
  • Flash Point: °C
  • Molecular Weight: 0
  • InChI: InChI=1/C35H30N4O4/c1-34(42-4)30(37(3)32(41)19-12-6-5-7-13-19)33-38-23-16-10-8-14-20(23)26-27-22(18-36-31(27)40)25-21-15-9-11-17-24(21)39(29(25)28(26)38)35(34,2)43-33/h5-17,30,33H,18H2,1-4H3,(H,36,40)/t30-,33-,34-,35+/m1/s1
  • Molecular Formula: C35H30 N4 O4
  • Molecular Structure:CAS No:120685-11-2 Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-

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120685-11-2 Midostaurin

  • Midostaurin is a multi-target protein kinase inhibitor being investigated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). https://www.bocsci.com/midostaurin-cas-120685-11-2-item-162132.html
  • Min. Order: 10
  • United States BOC Sciences [Manufacturer]
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120685-11-2 Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-

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120685-11-2 Midostaurin

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
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  • Address: 922 Clint Moore Road
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120685-11-2 PKC412

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
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120685-11-2 Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-

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120685-11-2 SC-200691 PKC-412

  • United States Santa Cruz Biotechnology, Inc. [Manufacturer]
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120685-11-2 PKC412 CGP41251; 4''-N-BENZOYLSTAUROSPORINE; MIDOSTAURIN

  • United States LC Laboratories [Manufacturer]
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References of Benzamide,N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
Title: Midostaurin
CAS Registry Number: 120685-11-2
CAS Name: N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3￠,2￠,1￠-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide
Synonyms: N-benzoylstaurosporine
Manufacturers' Codes: CGP-41251; PKC-412
Molecular Formula: C35H30N4O4
Molecular Weight: 570.64
Percent Composition: C 73.67%, H 5.30%, N 9.82%, O 11.22%
Literature References: Protein kinase C inhibitor; derivative of the naturally occurring alkaloid, staurosporine, q.v. Prepn: G. Caravatti, A. Fredenhagen, EP 296110; eidem, US 5093330 (1988, 1992 both to Ciba-Geigy); G. Caravatti et al., Bioorg. Med. Chem. Lett. 4, 399 (1994). HPLC determn in plasma: R. van Gijn et al., J. Chromatogr. B 667, 269 (1995). Review of pharmacology: D. Fabbro et al., Pharmacol. Ther. 82, 293-301 (1999); of mechanism of action and therapeutic potential: A. Gescher, Crit. Rev. Oncol. Hematol. 34, 127-135 (2000). Clinical pharmacokinetics and tolerability: D. J. Propper et al., J. Clin. Oncol. 19, 1485 (2001). Clinical evaluation in diabetic macular edema: P. A. Campochiaro et al., Invest. Ophthalmol. Visual Sci. 45, 922 (2004); in acute myeloid leukemia: R. M. Stone et al., Blood 105, 54 (2005).
Properties: mp 235-247° with darkening.
Melting point: mp 235-247° with darkening
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products.