Home > Name List By other > (2R,3R,4S, 5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

CAS No 123318-82-1 , (2R,3R,4S,
5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

  • Name: (2R,3R,4S,
    5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
  • Synonyms: Clofarex;Clolar; Evoltra; clofarabinum;(2R,3R,4S,
    5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; Cl-F-Ara-A; CAFdA; C1-F-Ara-A; clofarabina; 123318-82-1;
  • CAS Registry Number:
  • Melting Point: 228-2310C
  • Density: 2.12 g/cm3
  • Refractive index: 1.843
  • Safety Statements: Mutation data reported. When heated to decomposition it emits toxic vapors of NOx, F−, and Cl−.
  • Molecular Weight: 303.677443
  • InchiKey: WDDPHFBMKLOVOX-AYQXTPAHSA-N
  • InChI: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3
    (1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
  • Molecular Formula: C10H11ClFN5O3
  • Molecular Structure:CAS No:123318-82-1 (2R,3R,4S,<br />5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
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123318-82-1 (2R,3R,4S, 5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

  • CBNumber: CB2277491 Chemical Name: Clofarabine Molecular Formula: C10H11ClFN5O3 Formula Weight: 303.68 CAS No.: 123318-82-1
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  • China Wuhu Nowe Chemical Technologies Co,Ltd. [Manufacturer]
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123318-82-1 Clofarabine

  • Creative Enzymes uses its expertise in enzyme manufacturing to supply customers enzymes using for life science research and production of medicines, food, alcohol, beer, fruit juice, fabric, paper, leather goods, etc. We provide Clofarabine. More inf...
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  • United States Creative Enzymes [Manufacturer]
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  • Address: Shirley New York,New YorkUnited States
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123318-82-1 (2R,3R,4S, 5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

  • name clofarabine CAS NO 123318-82-1 quality 99%min in-house standard
  • China Shanghai BioGene Pharmacetical Co.,Ltd [Manufacturer]
  • Tel: 86-576-88702853
  • Address: Shanghai Jinshan Town shanghai,ShanghaiChina
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123318-82-1 Clofarabine

  • CAS No.: 123318-82-1 Name: Clofarabine Molecular Structure of 123318-82-1 (Clofarabine) Formula: C10H11ClFN5O3 Molecular Weight: 303.71
  • China Shanghai BioGene Pharmacetical Co.,Ltd [Manufacturer]
  • Tel: 86-576-88702853
  • Address: Shanghai Jinshan Town shanghai,ShanghaiChina
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123318-82-1 Clofarabine

  • China Chemrio International Limited [Manufacturer]
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  • Address: Chemrio International Limited
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123318-82-1 A1014 CLOFARABINE

  • United Kingdom Carbosynth Limited [Manufacturer]
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  • Address: Carbosynth Limited
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    UK null,nullUnited Kingdom
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123318-82-1 clofarabine

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123318-82-1 Clofarabine

  • China Trust&We Co., Ltd. [Manufacturer]
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123318-82-1 clofarabine

  • China Shanghai Yingxuan Chempharm Co., Ltd. [Manufacturer]
  • Tel: 86-21-50323911
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  • Address: Shanghai Yingxuan Chempharm Co., Ltd.
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    CN-201206,China null,nullChina
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References of (2R,3R,4S,
5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Title: Clofarabine
CAS Registry Number: 123318-82-1
CAS Name: 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
Synonyms: 2-chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)adenine; 2-chloro-2¢-arabinofluoro-2¢-deoxyadenosine; Cl-F-ara-A
Trademarks: Clolar (Genzyme)
Molecular Formula: C10H11ClFN5O3
Molecular Weight: 303.68
Percent Composition: C 39.55%, H 3.65%, Cl 11.67%, F 6.26%, N 23.06%, O 15.81%
Literature References: Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Prepn: K. A. Watanabe et al., EP 219829; eidem, US 4918179 (1987, 1990 both to Sloan-Kettering Inst. Cancer Res.); J. A. Montgomery et al., J. Med. Chem. 35, 397 (1992). Improved synthesis: W. E. Bauta et al., Org. Process Res. Dev. 8, 889 (2004). Antineoplastic activity: W. R. Waud et al., Nucleosides Nucleotides Nucleic Acids 19, 447 (2000). Clinical pharmacology: H. M. Kantarjian et al,. J. Clin. Oncol. 21, 1167 (2003). Clinical pharmacokinetics: V. Gandhi et al., Clin. Cancer Res. 9, 6335 (2003). Clinical evaluation in acute leukemia: H. Kantarjian et al., Blood 102, 2379 (2003); in pediatric patients: S. Jeha et al., ibid. 103, 784 (2004). Review of development: A. Sternberg, Curr. Opin. Invest. Drugs 4, 1479-1487 (2003); of mechanism of action and clinical experience: S. Faderl et al., Cancer 103, 1985-1995 (2005).
Properties: Crystals from water, mp 225-227° (Montgomery). Also reported as crystals from methanol, mp 237° (Bauta). uv max (water): 212, 263 nm (e 22500, 15989).
Melting point: mp 225-227° (Montgomery); crystals from methanol, mp 237° (Bauta)
Absorption maximum: uv max (water): 212, 263 nm (e 22500, 15989)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Purine Analogs.