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CAS No 124858-35-1 , Nadifloxacin

  • Name: Nadifloxacin
  • Synonyms: Nadifloxacino;Nadifloxacin; Nadifloxacinum; S-Nadifloxacin;jinofloxacin; OPC-7251; Nadixa; Nadifloxacine; Acuatim; 124858-35-1;
  • CAS Registry Number:
  • Melting Point: 245-2470C (dec)
  • Flash Point: 331.7 ºC
  • Boiling Point: 624.9 ºC at 760 mmHg
  • Density: 1.46 g/cm3
  • Refractive index: 1.668
  • Flash Point: 331.7 ºC
  • Molecular Weight: 360.379443
  • InchiKey: JYJTVFIEFKZWCJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-
    15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
  • Molecular Formula: C19H21FN2O4
  • Molecular Structure:CAS No:124858-35-1 Nadifloxacin

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References of Nadifloxacin
Title: Nadifloxacin
CAS Registry Number: 124858-35-1
CAS Name: 9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
Synonyms: jinofloxacin
Manufacturers' Codes: OPC-7251
Trademarks: Acuatim (Otsuka)
Molecular Formula: C19H21FN2O4
Molecular Weight: 360.38
Percent Composition: C 63.32%, H 5.87%, F 5.27%, N 7.77%, O 17.76%
Literature References: Fluorinated quinolone antibacterial. Prepn: H. Ishikawa et al., BE 891046; eidem, US 4399134 (1982, 1983 both to Otsuka); eidem, Chem. Pharm. Bull. 37, 2103 (1989). Toxicity data: K. Hashimoto et al., Iyakuhin Kenkyu 21, 671 (1990), C.A. 114, 156625r (1991). In vitro antibacterial activity: K. Vogt et al., Eur. J. Clin. Microbiol. Infect. Dis. 11, 943 (1992). HPLC determn: M. Koike et al., J. Chromatogr. 526, 235 (1990). Clinical trial in treatment of acne: I. Kurokawa et al., J. Am. Acad. Dermatol. 25, 674 (1991).
Properties: Colorless prisms from EtOH-H2O, mp 245-247° (dec). LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto).
Melting point: mp 245-247° (dec)
Toxicity data: LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto)
Therap-Cat: Antibacterial (topical).
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.