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CAS No 129497-78-5 , Verteporfin

  • Name: Verteporfin
  • Synonyms: trans-3,4-Dicarboxy-4,4a-dihydro-4a,8,14,19-tetramethyl-18-vinyl-23H,25H-benzo(b)porphine-9,13-dipropionic acid 3,4,9-trimethyl ester;Verteporfin;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: g/cm3
  • Flash Point: °C
  • Molecular Weight: 718.79
  • InChI: InChI=1/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)25(12-15-37(48)51-6)33(44-30)18-32-24(11-14-36(46)47)21(3)28(43-32)16-31(23)42-29/h9-10,13,16-19,38,43,45H,1,11-12,14-15H2,2-8H3,(H,46,47)/b31-16-,33-18-,34-17-,35-19-/t38-,41+/m0/s1
  • Molecular Formula: C41H42N4O8
  • Molecular Structure:CAS No:129497-78-5 Verteporfin

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129497-78-5 Verteporfin

  • Verteporfin Verteporfin(CL 318952; Visudyne), a benzoporphyrin derivative monoacid ring A, is a photosensitising drug for photodynamic therapy (PDT) activated by low-intensity, nonheat-generating light of 689nm wavelength. Target: others Verteporfin ...
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129497-78-5 VERTEPORFIN

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129497-78-5 VERTEPORFIN

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129497-78-5 Verteporfin

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References of Verteporfin
Title: Verteporfin
CAS Registry Number: 129497-78-5
CAS Name: (4R,4aS)-rel-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Synonyms: BPD-MA
Manufacturers' Codes: CL-318952
Trademarks: Visudyne (Novartis)
Molecular Formula: C41H42N4O8
Molecular Weight: 718.79
Percent Composition: C 68.51%, H 5.89%, N 7.79%, O 17.81%
Literature References: Benzoporphyrin photosensitizer. Preparative method: A. M. Richter et al., J. Natl. Cancer Inst. 79, 1327 (1987). Photosensitizing efficiency: A. M. Richter et al., Biochem. Pharmacol. 43, 2349 (1992). Spectral characterization: R. Gillies et al., J. Photochem. Photobiol. B 33, 87 (1996). Tissue uptake parameters: R. K. Chowdhary et al., Biopharm. Drug Dispos. 19, 395 (1998). Clinical trial in macular degeneration: TAP Study Group, Arch. Ophthalmol. 117, 1329 (1999). Review of pharmacology and clinical experience: K. J. Mellish, S. B. Brown, Expert Opin. Pharmacother. 2, 351-361 (2001); S. J. Bakri, P. K. Kaiser, ibid. 5, 195-203 (2004).
Properties: Virtually insol in water. Absorption max: ~690 nm.
Absorption maximum: Absorption max: ~690 nm
NOTE: The marketed form is a mixture of the two possible methyl esters.
Therap-Cat: In treatment of age-related macular degeneration.
Keywords: Macular Degeneration Treatment.