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CAS No 13010-47-4 , 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

  • Name: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
  • Synonyms: CCNU; 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; 13010-47-4; Chloroethylcyclohexylnitrosourea; CINU; Cecenu; CeeNU;Belustine;1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 88-90 ºC
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.35 g/cm3
  • Refractive index: 1.57
  • Safety Statements: Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, intravenous, and possibly other routes. Human systemic effects by ingestion: anorexia, nausea or vomiting, leukopenia (decrease in the white blood cell count), and thrombocytopenia (decrease in the number of blood platelets). Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also N-NITROSO COMPOUNDS.
  • Hazard Symbols: T: Toxic;
  • Flash Point: °C
  • EINECS: 235-859-2
  • Molecular Weight: 233.69524
  • InchiKey: GQYIWUVLTXOXAJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,
    (H,11,14)
  • Risk Statements: 45-25
  • Molecular Formula: C9H16ClN3O2
  • Molecular Structure:CAS No:13010-47-4 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

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References of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Title: Lomustine
CAS Registry Number: 13010-47-4
CAS Name: N-(2-Chloroethyl)-N￠-cyclohexyl-N-nitrosourea
Synonyms: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Manufacturers' Codes: NSC-79037; RB-1509
Trademarks: Belustine (Bellon); CCNU (Lundbeck); Cecenu (Medac); CeeNU (BMS); CiNU (BMS)
Molecular Formula: C9H16ClN3O2
Molecular Weight: 233.70
Percent Composition: C 46.25%, H 6.90%, Cl 15.17%, N 17.98%, O 13.69%
Literature References: Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine, q.q.v. Synthesis: T. P. Johnston et al., J. Med. Chem. 9, 892 (1966). Clinical review: S. K. Carter, J. W. Newman, Cancer Chemother. Rep. Part 3 1, 136 (1968). Physiological disposition: V. T. Oliverio et al., Cancer Res. 30, 1330 (1970). Toxicology and pharmacology: G. R. Thompson, R. E. Larson, Toxicol. Appl. Pharmacol. 21, 405 (1972); V. T. Oliverio, Cancer Chemother. Rep. Part 3 4, 13 (1973). Comprehensive description: F. J. Al-Shammary, Anal. Profiles Drug Subs. 19, 315-340 (1990).
Properties: Yellow powder, mp 90°. Freely sol in chloroform; sol in ethanol, acetone. Soly in water, 0.1N NaOH, 0.1N HCl or 10% ethanol: <0.05 mg/ml; in absolute ethanol: 70 mg/ml. The bulk drug should be stored in a deep freeze and protected from moisture. LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson).
Melting point: mp 90°
Toxicity data: LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson)
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-52.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrosoureas.