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CAS No 13010-47-4 , 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

  • Name: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
  • Synonyms: CCNU; 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; 13010-47-4; Chloroethylcyclohexylnitrosourea; CINU; Cecenu; CeeNU;Belustine;1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 88-90 ºC
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.35 g/cm3
  • Refractive index: 1.57
  • Safety Statements: Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, intravenous, and possibly other routes. Human systemic effects by ingestion: anorexia, nausea or vomiting, leukopenia (decrease in the white blood cell count), and thrombocytopenia (decrease in the number of blood platelets). Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also N-NITROSO COMPOUNDS.
  • Hazard Symbols: T: Toxic;
  • Flash Point: °C
  • EINECS: 235-859-2
  • Molecular Weight: 233.69524
  • InchiKey: GQYIWUVLTXOXAJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,
    (H,11,14)
  • Risk Statements: 45-25
  • Molecular Formula: C9H16ClN3O2
  • Molecular Structure:CAS No:13010-47-4 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
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13010-47-4 Lomustine

  • By damaging the DNA, lomustine inhibits cancer cells and stops cells from dividing. Lomustine inhibits the growth of ZR-75-1 and U373 with IC50 of 12 uM and 15 uM, respectively. Lomustine reduces the level of expression of the DNA repair protein O6-a...
  • Min. Order: 10
  • United States Creative Enzymes [Manufacturer]
  • Tel: 1-631-6197922
  • Fax: 1-631-9388127
  • Address: Shirley New York,New YorkUnited States
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13010-47-4 LOMUSTINE(CCNU) CP2000,BP2000, EP3RD ANTINEOPLASTIC DRUGS

  • LOMUSTINE(CCNU) CP2000,BP2000, EP3RD ANTINEOPLASTIC DRUGS
  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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13010-47-4 Lomustine

  • Lomustine
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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13010-47-4 Lomustine

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13010-47-4 Lomustine

  • Lomustine 13010-47-4 B136649
  • China bepharm ltd. null
  • Tel: 86-21-51816456
  • Address: 128 Xiangyin Road, Room C320-321 Yangpu District, Shanghai 200433, China null,nullChina
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13010-47-4 Lomustine

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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13010-47-4 LOMUSTINE

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13010-47-4 Lomustine

  • Lomustine, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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13010-47-4 Lomustine

  • Lomustine
  • China Betapharma Shanghai Inc.Co., Ltd [Manufacturer]
  • Tel: 86-21-62951620
  • Fax: 86-21-32230794
  • Address: Jinming Building 12A No. 8 Zunyi(S) Rd. Shanghai China 200336 shanghaiCHINA shanghai,nullChina
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13010-47-4 Lomustine

  • Lomustine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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References of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Title: Lomustine
CAS Registry Number: 13010-47-4
CAS Name: N-(2-Chloroethyl)-N¢-cyclohexyl-N-nitrosourea
Synonyms: 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Manufacturers' Codes: NSC-79037; RB-1509
Trademarks: Belustine (Bellon); CCNU (Lundbeck); Cecenu (Medac); CeeNU (BMS); CiNU (BMS)
Molecular Formula: C9H16ClN3O2
Molecular Weight: 233.70
Percent Composition: C 46.25%, H 6.90%, Cl 15.17%, N 17.98%, O 13.69%
Literature References: Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine, q.q.v. Synthesis: T. P. Johnston et al., J. Med. Chem. 9, 892 (1966). Clinical review: S. K. Carter, J. W. Newman, Cancer Chemother. Rep. Part 3 1, 136 (1968). Physiological disposition: V. T. Oliverio et al., Cancer Res. 30, 1330 (1970). Toxicology and pharmacology: G. R. Thompson, R. E. Larson, Toxicol. Appl. Pharmacol. 21, 405 (1972); V. T. Oliverio, Cancer Chemother. Rep. Part 3 4, 13 (1973). Comprehensive description: F. J. Al-Shammary, Anal. Profiles Drug Subs. 19, 315-340 (1990).
Properties: Yellow powder, mp 90°. Freely sol in chloroform; sol in ethanol, acetone. Soly in water, 0.1N NaOH, 0.1N HCl or 10% ethanol: <0.05 mg/ml; in absolute ethanol: 70 mg/ml. The bulk drug should be stored in a deep freeze and protected from moisture. LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson).
Melting point: mp 90°
Toxicity data: LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson)
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-52.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrosoureas.