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CAS No 132539-06-1 , 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine

  • Name: 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
  • Synonyms: Olansek; Zyprexa Intramuscular; Zyprexa Zydis; 132539-06-1; Lanzac; Symbyax;Zyprexa; Zalasta; Zydis;2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine;
  • CAS Registry Number:
  • Flash Point: 233.6 ºC
  • Boiling Point: 462.6 ºC at 760 mmHg
  • Density: 1.32 g/cm3
  • Refractive index: 3.3
  • Water Solubility: Practically insoluble in water mg/mL (20 oC)
  • Flash Point: 233.6 ºC
  • Molecular Weight: 312.4325
  • InchiKey: WXPNDRBBWZMPQG-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15
    (14)19-17(13)22-12/h3-6,11,18H,7-10H2,1-2H3
  • Molecular Formula: C17H20N4S
  • Molecular Structure:CAS No:132539-06-1 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine

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References of 2-methyl-4-(4-methylpiperazin-1-yl)-5H-thieno[3,2-c][1,5]benzodiazepine
Title: Olanzapine
CAS Registry Number: 132539-06-1
CAS Name: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
Manufacturers' Codes: LY-170053
Trademarks: Zyprexa (Lilly)
Molecular Formula: C17H20N4S
Molecular Weight: 312.43
Percent Composition: C 65.35%, H 6.45%, N 17.93%, S 10.26%
Literature References: Serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Prepn: J. K. Chakrabarti et al., EP 454436; eidem, US 5229382 (1991, 1993 both to Lilly). Comparative pharmacology: N. A. Moore et al., Curr. Opin. Invest. Drugs 2, 281 (1993). HPLC determn in human plasma: J. T. Catlow et al., J. Chromatogr. B 668, 85 (1995). Clinical evaluation in schizophrenia: D. S. Baldwin, S. A. Montgomery, Int. Clin. Psychopharmacol. 10, 239 (1995); in mania of bipolar disorder: M. Tohen et al., Am. J. Psychiatry 156, 702 (1999). Review of pharmacology and clinical experience: B. C. Lund, P. J. Perry, Expert Opin. Pharmacother. 1, 305-323 (2000).
Properties: Crystals from acetonitrile, mp 195°. Practically insol in water.
Melting point: mp 195°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Other Tricyclics; Serotonin-Dopamine Antagonist.