Home > Name List By other > (2S,3R,4S,5S, 6R)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4, 5-triol

CAS No 132682-98-5 , (2S,3R,4S,5S,
6R)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,
5-triol

  • Name: (2S,3R,4S,5S,
    6R)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,
    5-triol
  • Synonyms: Glucosyl-ifosfamide mustard;Glufosfamide;(2S,3R,4S,5S,
    6R)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,
    5-triol; MolPort-005-942-376; glc-IPM; AC1L3X04; D 19575; UNII-1W5N8SZD9A; HSDB 7024; Glucosylifostamide mustard;
  • CAS Registry Number:
  • Flash Point: 298.5°C
  • Boiling Point: 569.9°Cat760mmHg
  • Density: 1.56g/cm3
  • Refractive index: 1.563
  • Flash Point: 298.5°C
  • Molecular Weight: 383.162702
  • InchiKey: PSVUJBVBCOISSP-SPFKKGSWSA-N
  • InChI: InChI=1S/C10H21Cl2N2O7P/c11-1-3-13-22(19,
    14-4-2-12)21-10-9(18)8(17)7(16)6(5-15)20-10/h6-10,15-18H,1-5H2,(H2,13,
    14,19)/t6-,7-,8+,9-,10+/m1/s1
  • Molecular Formula: C10H21Cl2N2O7P
  • Molecular Structure:CAS No:132682-98-5 (2S,3R,4S,5S,<br />6R)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,<br />5-triol

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132682-98-5 GLUFOSFAMIDE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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132682-98-5 Glufosfamide

  • Glufosfamide, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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132682-98-5 GLUFOSFAMIDE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of (2S,3R,4S,5S,
6R)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,
5-triol
Title: Glufosfamide
CAS Registry Number: 132682-98-5
CAS Name: 1-[N,N￠-Bis(2-chloroethyl)phosphorodiamidate]-b-D-glucopyranose
Synonyms: b-D-glucopyranosyl N,N￠-di(2-chloroethyl) phosphoric acid diamide; b-D-glucosylisophosphoramide mustard
Manufacturers' Codes: D-19575
Molecular Formula: C10H21Cl2N2O7P
Molecular Weight: 383.16
Percent Composition: C 31.35%, H 5.52%, Cl 18.51%, N 7.31%, O 29.23%, P 8.08%
Literature References: Glucose coupled to isophosphoramide mustard, the active metabolite of the alkylating agent ifosfamide, q.v. Enters cells through upregulated glucose transport proteins. Prepn: M. Wiessler, M. Dickes, DE 3835772; eidem, US 5622936 (1990, 1997 both to Deutsches Krebsforschungszentrum Stiftung). Pharmacology and toxicity studies: J. Pohl et al., Cancer Chemother. Pharmacol. 35, 364 (1995). Mechanism of action study: H. Seker et al., Br. J. Cancer 82, 629 (2000). Clinical evaluation in pancreatic cancer: E. Briasoulis et al., Eur. J. Cancer 39, 2334 (2003); in non-small cell lung cancer: G. Giaccone et al., ibid. 40, 667 (2004). Review of pharmacology and clinical development: I. Niculescu-Duvaz, Curr. Opin. Invest. Drugs 3, 1527-1532 (2002).
Properties: LD50 in rats, mice (mg/kg): 1575, 1575 i.v.; 1470, 1470 orally (Pohl).
Toxicity data: LD50 in rats, mice (mg/kg): 1575, 1575 i.v.; 1470, 1470 orally (Pohl)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrogen Mustards.