Home > Name List By other > (3R, 5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2- ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid

CAS No 134523-00-5 , (3R,
5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-
ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid

  • Name: (3R,
    5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-
    ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
  • Synonyms: Torvast; Sotis; Lipotropic; Faboxim;Cardyl;(3R,
    5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-
    ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid; Tozalip; Lipitor; Atorpic; Xavator;
  • CAS Registry Number:
  • Density: 1.23 g/cm3
  • Safety Statements: S26;S36;
  • Hazard Symbols: Xn
  • Molecular Weight: 558.639803
  • InchiKey: XUKUURHRXDUEBC-KAYWLYCHSA-N
  • InChI: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-
    3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28
    (39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,
    27-/m1/s1
  • Risk Statements: 20/21/22-36/37/38
  • Molecular Formula: C33H35FN2O5
  • Molecular Structure:CAS No:134523-00-5 (3R,<br />5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-<br />ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
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134523-00-5 Atorvastatin

  • Germany Fox Chemicals GmbH [Manufacturer]
  • Tel: +49.7240.927151/ +49.160.95781845 (Mobile)
  • Fax: +49.7240.927150
  • Address: Fox Chemicals GmbH
    Bockstalstr.10 A
    D-76327 Pfinztal-Germany null,nullGermany
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134523-00-5 Atorvastatin

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
  • Fax: +91-22-6693 5687
  • Address: 110 & 111, Kartik Complex
    New link Road, Andheri-(W)
    Mumbai-400053, INDIA. null,nullIndia
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134523-00-5 ATORVASTATIN CALCIUM

  • ATORVASTATIN CALCIUM
  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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134523-00-5 AtorvastatinCalcium

  • AtorvastatinCalcium
  • China Pharmasi Chemicals Co.Ltd [Manufacturer]
  • Tel: +86-21-67752521
  • Fax: +86-21-57819315
  • Address: Pharmasi Chemicals Co.Ltd
    Address: Room 903,
    JIAHE business building,
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134523-00-5 ATORVASTATIN CALCIUM TABLETS

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
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  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
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134523-00-5 Atorvastatin Calcium

  • Atorvastatin Calcium, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
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  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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134523-00-5 Atorvastatin calcium

  • Atorvastatin calcium
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
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  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
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134523-00-5 Atorvastatin

  • China Hangzhou Sage Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-571-86818502
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  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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134523-00-5 Atorvastatin Calcium

  • Atorvastatin Calcium
  • China Betapharma Shanghai Inc.Co., Ltd [Manufacturer]
  • Tel: 86-21-62951620
  • Fax: 86-21-32230794
  • Address: Jinming Building 12A No. 8 Zunyi(S) Rd. Shanghai China 200336 shanghaiCHINA shanghai,nullChina
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134523-00-5 Atorvastatin calcium

  • Atorvastatin calcium
  • China Shenzhen sailing chemical Co.,Ltd [Manufacturer]
  • Tel: 86-755-26415005
  • Fax: 86-755-26412646
  • Address: 1-403 Bei tou hao yuan Nanxing Road Nanshan District Shenzhen, Guangdong 518051 shenzhenCHINA shenzhen,nullChina
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References of (3R,
5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-
ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
Title: Atorvastatin
CAS Registry Number: 134523-00-5
CAS Name: (bR,dR)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
Molecular Formula: C33H35FN2O5
Molecular Weight: 558.64
Percent Composition: C 70.95%, H 6.31%, F 3.40%, N 5.01%, O 14.32%
Literature References: HMG-CoA reductase inhibitor. Prepn: B. D. Roth, EP 409281; idem, US 5273995 (1991, 1993 both to Warner-Lambert); K. L. Baumann et al., Tetrahedron Lett. 33, 2283 (1992). Solubility and kinetic studies: A. S. Kearney et al., Pharm. Res. 10, 1461 (1993). LC/MS/MS determn in serum: M. Jemal et al., Rapid Commun. Mass Spectrom. 13, 1003 (1999). Clinical pharmacokinetics: D. D. Cilla, Jr. et al., Clin. Pharmacol. Ther. 60, 687 (1996). Review of pharmacology and clinical experience: H. S. Yee, N. T. Fong, Ann. Pharmacother. 32, 1030-1043 (1998); of efficacy in diabetic patients: K. F. Croom, G. L. Plosker, Drugs 65, 137-152 (2005).
 
Derivative Type: Calcium salt trihydrate
CAS Registry Number: 344423-98-9; 134523-03-8 (anhydrous)
Manufacturers' Codes: CI-981
Trademarks: Lipitor (Parke-Davis); Sortis (Pfizer); Torvast (Pfizer); Totalip (Guidotti)
Molecular Formula: C66H68CaF2N4O10.3H2O
Molecular Weight: 1209.39
Percent Composition: C 65.55%, H 6.17%, Ca 3.31%, F 3.14%, N 4.63%, O 17.20%
Properties: White to off-white crystalline powder. [a]D -7.4° (c = 1 in DMSO). Freely sol in methanol; slightly sol in ethanol; very slightly sol in acetonitrile, distilled water, phosphate buffer (pH 7.4). Insol in aq solns of pH 4 and below.
Optical Rotation: [a]D -7.4° (c = 1 in DMSO)
 
Derivative Type: Sodium salt
CAS Registry Number: 134523-01-6
Molecular Formula: C33H34FN2NaO5
Molecular Weight: 580.62
Percent Composition: C 68.26%, H 5.90%, F 3.27%, N 4.82%, Na 3.96%, O 13.78%
Properties: pKa 4.46. Soly in water (30°): 20.4 mg/ml (pH 2.1); 1.23 mg/ml (pH 6.0).
pKa: pKa 4.46
 
Derivative Type: Lactone
CAS Registry Number: 125995-03-1
CAS Name: 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
Molecular Formula: C33H33FN2O4
Molecular Weight: 540.62
Percent Composition: C 73.31%, H 6.15%, F 3.51%, N 5.18%, O 11.84%
Properties: mp 159.2-160.7°. [a]D +26.05° (c = 1 in chloroform).
Melting point: mp 159.2-160.7°
Optical Rotation: [a]D +26.05° (c = 1 in chloroform)
 
Therap-Cat: Antilipemic.
Keywords: Antilipemic; HMG CoA Reductase Inhibitors; HMG CoA Reductase Inhibitor.