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CAS No 13539-59-8 , 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,
4]benzotriazine-1,3-dione

  • Name: 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,
    4]benzotriazine-1,3-dione
  • Synonyms: Sinnamin; Rheumox; Cinnopropazone; APAZONE;5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,
    4]benzotriazine-1,3-dione; Azapropazona; Azapropazonum; Prolixan; Mitrolan; Cinnamin;Azapropazone;
  • CAS Registry Number:
  • Flash Point: 218.7°C
  • Boiling Point: 438°Cat760mmHg
  • Density: 1.29g/cm3
  • Refractive index: 1.646
  • Safety Statements: Moderately toxic by ingestion, intraperitoneal and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 218.7°C
  • EINECS: 236-913-8
  • Molecular Weight: 300.3556
  • InchiKey: MPHPHYZQRGLTBO-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)
    20(19)15(11)22/h7-9,11H,5-6H2,1-4H3
  • Molecular Formula: C16H20N4O2
  • Molecular Structure:CAS No:13539-59-8 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,<br />4]benzotriazine-1,3-dione

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References of 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,
4]benzotriazine-1,3-dione
Title: Apazone
CAS Registry Number: 13539-59-8
CAS Name: 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione
Synonyms: 3-dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine; azapropazone
Manufacturers' Codes: AHR-3018; MI-85
Trademarks: Cinnamin (Nippon Chemiphar)
Molecular Formula: C16H20N4O2
Molecular Weight: 300.36
Percent Composition: C 63.98%, H 6.71%, N 18.65%, O 10.65%
Literature References: Prepn: FR 1440629; I. Molnar et al., US 3349088 (1966, 1967, both to Siegfried); Mixich, Helv. Chim. Acta 51, 532 (1968). Pharmacological and toxicological studies: Jahn, Adrian, Arzneim.-Forsch. 19, 36 (1969). Metabolism: Mixich, Helv. Chim. Acta 55, 1031 (1972). HPLC determn in plasma and urine: B. J. Kline et al., Arzneim.-Forsch. 33, 504 (1983).
Properties: mp 228°.
Melting point: mp 228°
 
Derivative Type: Dihydrate
CAS Registry Number: 22304-30-9
Manufacturers' Codes: MI-85Di
Trademarks: Prolixan (Siegfried); Rheumox (Goldshield); Tolyprin (DuPont)
Properties: Almost colorless crystals, mp 247-248°.
Melting point: mp 247-248°
 
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Pyrazolones.