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CAS No 137-58-6 , 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

  • Name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
  • Synonyms: Leostesin;Xylocaine;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide; Lidoderm; Lignocaine; Gravocain; Maricaine; Esracaine; Anestacon; Alphacaine;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 66-69 ºC
  • Flash Point: 166°C
  • Boiling Point: 350.8°Cat760mmHg
  • Density: 1.026g/cm3
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 166°C
  • EINECS: 205-302-8
  • Molecular Weight: 234.33728
  • InchiKey: NNJVILVZKWQKPM-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,
    5-6,10H2,1-4H3,(H,15,17)
  • Risk Statements: S22;S26;S36
  • Molecular Formula: C14H22N2O
  • Molecular Structure:CAS No:137-58-6 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

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    References of 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
    Title: Lidocaine
    CAS Registry Number: 137-58-6
    CAS Name: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
    Synonyms: 2-diethylamino-2￠,6￠-acetoxylidide; w-diethylamino-2,6-dimethylacetanilide; lignocaine
    Trademarks: Cuivasil (IDC); Lidoderm (Hind); LidoPosterine (Kade); Vagisil (Combe)
    Molecular Formula: C14H22N2O
    Molecular Weight: 234.34
    Percent Composition: C 71.75%, H 9.46%, N 11.95%, O 6.83%
    Literature References: Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. Prepn: N. M. L?fgren, B. J. Lundqvist, US 2441498 (1948 to Astra); A. D. H. Self, A. P. T. Easson, GB 706409 (1954 to May & Baker); I. P. S. Hardie, E. S. Stern, GB 758224 (1956 to J. F. Macfarlane & Co.); Zhuravlev, Nikolaev, Zh. Obshch. Khim. 30, 1155 (1960). Toxicity studies: E. R. Smith, B. R. Duce, J. Pharmacol. Exp. Ther. 179, 580 (1971); G. H. Kronberg et al., J. Med. Chem. 16, 739 (1973). Review of pharmacokinetics: N. L. Benowitz, W. Meister, Clin. Pharmacokinet. 3, 177 (1978). Review of action as local anesthetic: L?fgren, Studies on Local Anesthetics: Xylocaine, A New Synthetic Drug (Hoeggstroms, Stockholm, 1948); Cooper, Pharm. J. 171, 68 (1953). Reviews of anti-arrhythmic agents: J. L. Anderson et al., Drugs 15, 271 (1978); L. H. Opie, Lancet 1, 861 (1980); E. Carmeliet, Ann. N.Y. Acad. Sci. 427, 1 (1984). Comprehensive description: K. Groningsson et al., Anal. Profiles Drug Subs. 14, 207-243 (1985); M. F. Powell, ibid. 15, 761-779 (1986). Review of use in treatment of postherpetic neuralgia: P. S. Davies, B. S. Galer, Drugs 64, 937-947 (2004).
    Properties: Needles from benzene or alcohol, mp 68-69°. bp4 180-182°; bp2 159-160°. Insol in water. Sol in alcohol, ether, benzene, chloroform, oils. Partition coefficient (octanol/water, pH 7.4): 43.
    Melting point: mp 68-69°
    Boiling point: bp4 180-182°; bp2 159-160°
    Log P: Partition coefficient (octanol/water, pH 7.4): 43
     
    Derivative Type: Hydrochloride
    CAS Registry Number: 73-78-9; 6108-05-0 (monohydrate)
    Trademarks: Basicaina (Galenica); Batixim (So.Se.); Dynexan (Kreussler); Heweneural (Hevert); Licain (DeltaSelect); Lidesthesin (Ritsert); Lidofast (Angelini); Lidoject (Hexal); Lidrian (Baxter); Odontalg (Giovanardi); Sedagul (Wild); Xylocaine (AstraZeneca); Xylocard (AstraZeneca); Xylocitin (Jenapharm); Xyloneural (Strathmann)
    Molecular Formula: C14H22N2O.HCl
    Molecular Weight: 270.80
    Percent Composition: C 62.09%, H 8.56%, N 10.34%, O 5.91%, Cl 13.09%
    Properties: Crystals, mp 127-129°; monohydrate, mp 77-78°. Very sol in water, alcohol; sol in chloroform. Insol in ether. pH of 0.5% aq soln: 4.0-5.5. LD50 in mice (mg/kg): 292 orally (Smith, Duce); 105 i.p.; 19.5 i.v. (Kronberg).
    Melting point: mp 127-129°; mp 77-78°
    Toxicity data: LD50 in mice (mg/kg): 292 orally (Smith, Duce); 105 i.p.; 19.5 i.v. (Kronberg)
     
    Therap-Cat: Anesthetic (local); antiarrhythmic (class IB).
    Therap-Cat-Vet: Anesthetic (local).
    Keywords: Anesthetic (Local); Antiarrhythmic.