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CAS No 13739-02-1 , 4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid

  • Name: 4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid
  • Synonyms: Diacereine [French]; 13739-02-1;Diacerein; Diacereinum [Latin]; 4,5-Diacetylrhein; Fisiodar; Diacetylrhein; Diacerhein;4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid; Artrodar;
  • CAS Registry Number:
  • Density: 1.491 g/cm3
  • Refractive index: 1.634
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 237-310-2
  • Molecular Weight: 368.29378
  • InchiKey: TYNLGDBUJLVSMA-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10
    (19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
  • Risk Statements: S26;S36
  • Molecular Formula: C19H12O8
  • Molecular Structure:CAS No:13739-02-1 4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid

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References of 4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid
Title: Diacerein
CAS Registry Number: 13739-02-1
CAS Name: 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
Synonyms: 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid diacetate; 1,8-diacetoxy-3-carboxyanthraquinone; diacerhein; diacetylrhein; DAR
Manufacturers' Codes: SF-277
Trademarks: Artrodar (Proter); Fisiodar (Abiogen)
Molecular Formula: C19H12O8
Molecular Weight: 368.29
Percent Composition: C 61.96%, H 3.28%, O 34.75%
Literature References: Diacetyl derivative of rhein, q.v. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Prepn: A. Tschirch, K. Heuberger, Arch. Pharm. 240, 596 (1902); V. K. Murty et al., Tetrahedron 23, 515 (1967). Effect on prostaglandin release: P. Pomarelli et al., Farmaco Ed. Sci. 35, 836 (1980). Inhibition of proteases: L. Raimondi et al., Pharmacol. Res. Commun. 14, 103 (1982). Use in arthritis: C. A. Friedmann, DE 2711493; idem, US 4244968 (1977, 1981 both to Proter). Preliminary clinical study in osteoarthritis: A. G. Kay et al., Curr. Med. Res. Opin. 6, 548 (1980). Use in multiple sclerosis, amyotrophic lateral sclerosis: C. A. Friedmann, US 4346103 (1982); idem, JP Kokai 83 225015 (1983 to Proter), C.A. 100, 144991e (1984). Clinical trial in osteoarthritis: S. Adami et al., Clin. Ter. 112, 439 (1985).
Properties: Yellow plates from acetic acid, mp 217-218°.
Melting point: mp 217-218°
Therap-Cat: Antiarthritic.
Keywords: Antiarthritic/Antirheumatic.