Home > Name List By other > (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl] methyl]amino]butanoic acid

CAS No 137862-53-4 , (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]
methyl]amino]butanoic acid

  • Name: (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]
    methyl]amino]butanoic acid
  • Synonyms: Miten;(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]
    methyl]amino]butanoic acid; Tareg; Valsarran; Provas; Vals; Nisis; Kalpress; 137862-53-4;Diovan;
  • CAS Registry Number:
  • Transport: 10kgs
  • Melting Point: 116-117 ºC
  • Density: 1.212 g/cm3
  • Safety Statements: 26-37/39
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 435.51876
  • InchiKey: ACWBQPMHZXGDFX-QFIPXVFZSA-N
  • InChI: InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18
    (14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,
    15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C24H29N5O3
  • Molecular Structure:CAS No:137862-53-4 (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]<br />methyl]amino]butanoic acid

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References of (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]
methyl]amino]butanoic acid
Title: Valsartan
CAS Registry Number: 137862-53-4
CAS Name: N-(1-Oxopentyl)-N-[[2￠-(1H-tetrazol-5-yl)[1,1￠-biphenyl]-4-yl]methyl]-L-valine
Synonyms: N-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-N-valeryl-L-valine; (S)-N-(1-carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2￠-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amine
Manufacturers' Codes: CGP-48933
Trademarks: Diovan (Novartis); Tareg (Novartis)
Molecular Formula: C24H29N5O3
Molecular Weight: 435.52
Percent Composition: C 66.19%, H 6.71%, N 16.08%, O 11.02%
Literature References: Nonpeptide angiotensin II AT1-receptor antagonist. Prepn: P. Bühlmayer et al., EP 443983; eidem, US 5399578 (1991, 1995 both to Ciba Geigy); idem et al., Bioorg. Med. Chem. Lett. 4, 29 (1994). Pharmacological profile: L. Criscione et al., Br. J. Pharmacol. 110, 761 (1993). HPLC determn in human plasma: A. Sioufi et al., J. Liq. Chromatogr. 17, 2179 (1994). Clinical pharmacology: P. Müller et al., Eur. J. Clin. Pharmacol. 47, 231 (1994). Clinical comparison with captopril, q.v., in high risk patients following myocardial infarction: M. A. Pfeffer et al., N. Engl. J. Med. 349, 1893 (2003). Review of pharmacology and clinical experience in heart failure: R. Latini et al., Expert Opin. Pharmacother. 5, 181-193 (2004).
Properties: Crystals from diisopropyl ether, mp 116-117°. Partition coefficient (n-octanol/aq phosphate buffer): 0.033. Sol in water at 25°.
Melting point: mp 116-117°
Log P: Partition coefficient (n-octanol/aq phosphate buffer): 0.033
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive; Biphenyltetrazole Derivatives.