Home > Name List By 2 > 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1, 3-diazaspiro[4.4]non-1-en-4-one

CAS No 138402-11-6 , 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,
3-diazaspiro[4.4]non-1-en-4-one

  • Name: 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,
    3-diazaspiro[4.4]non-1-en-4-one
  • Synonyms: BMS-186295; Karvea; Aprovel;Avapro; Avalide; Irbesarran; Irbesartan [USAN:INN]; Lrbesartan; 138402-11-6;2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,
    3-diazaspiro[4.4]non-1-en-4-one;
  • CAS Registry Number:
  • Transport: HAZARD
  • Melting Point: 180-181 ºC
  • Density: 1.3 g/cm3
  • Refractive index: 1.689
  • Safety Statements: S26
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 428.52942
  • InchiKey: YOSHYTLCDANDAN-UHFFFAOYSA-N
  • InChI: InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-
    13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,
    6-7,10,15-17H2,1H3,(H,27,28,29,30)
  • Risk Statements: R22
  • Molecular Formula: C25H28N6O
  • Molecular Structure:CAS No:138402-11-6 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,<br />3-diazaspiro[4.4]non-1-en-4-one

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References of 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,
3-diazaspiro[4.4]non-1-en-4-one
Title: Irbesartan
CAS Registry Number: 138402-11-6
CAS Name: 2-Butyl-3-[[2￠-(1H-tetrazol-5-yl)[1,1￠-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Synonyms: 2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one; 2-n-butyl-4-spirocyclopentane-1-[(2￠-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one
Manufacturers' Codes: BMS-186295; SR-47436
Trademarks: Aprovel (Sanofi-Synthelabo); Avapro (Sanofi-Synthelabo)
Molecular Formula: C25H28N6O
Molecular Weight: 428.53
Percent Composition: C 70.07%, H 6.59%, N 19.61%, O 3.73%
Literature References: Angiotensin II type 1 (AII1)-receptor antagonist. Prepn: C. Bernhart et al., WO 9114679; eidem, US 5270317 (1991, 1993 both to Sanofi); eidem et al., J. Med. Chem. 36, 3371 (1993). HPLC determn in plasma and urine: S.-Y. Chang et al., J. Chromatogr. B 702, 149 (1997). Metabolism: T. J. Chando et al., Drug Metab. Dispos. 26, 408 (1998). Review of pharmacology and clinical efficacy: J. C. Gillis, A. Markham, Drugs 54, 885-902 (1997). Renoprotective effect in diabetic nephropathy: E. J. Lewis et al., N. Engl. J. Med. 345, 851 (2001); H.-H. Parving et al., ibid. 870.
Properties: Crystals from 96% ethanol, mp 180-181°.
Melting point: mp 180-181°
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive; Biphenyltetrazole Derivatives.