Home > Name List By 2 > 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1, 3-diazaspiro[4.4]non-1-en-4-one

CAS No 138402-11-6 , 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,
3-diazaspiro[4.4]non-1-en-4-one

  • Name: 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,
    3-diazaspiro[4.4]non-1-en-4-one
  • Synonyms: BMS-186295; Karvea; Aprovel;Avapro; Avalide; Irbesarran; Irbesartan [USAN:INN]; Lrbesartan; 138402-11-6;2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,
    3-diazaspiro[4.4]non-1-en-4-one;
  • CAS Registry Number:
  • Transport: HAZARD
  • Melting Point: 180-181 ºC
  • Density: 1.3 g/cm3
  • Refractive index: 1.689
  • Safety Statements: S26
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 428.52942
  • InchiKey: YOSHYTLCDANDAN-UHFFFAOYSA-N
  • InChI: InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-
    13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,
    6-7,10,15-17H2,1H3,(H,27,28,29,30)
  • Risk Statements: R22
  • Molecular Formula: C25H28N6O
  • Molecular Structure:CAS No:138402-11-6 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,<br />3-diazaspiro[4.4]non-1-en-4-one
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138402-11-6 Irbesartan (Avapro)

  • Creative Enzymes uses its expertise in enzyme manufacturing to supply customers enzymes using for life science research and production of medicines, food, alcohol, beer, fruit juice, fabric, paper, leather goods, etc. We provide Irbesartan (Avapro). ...
  • Min. Order: 10
  • United States Creative Enzymes [Manufacturer]
  • Tel: 1-631-6197922
  • Fax: 1-631-9388127
  • Address: Shirley New York,New YorkUnited States
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138402-11-6 Irbesartan

  • "Character White to off white crystalline powder, slightly soluble in alcohol and in methylene chloride, practically insoluble in water Identification A) IR spectrum is in accordance with the spectrum obtained with Irbesartan RS B) The retention time...
  • China Hangzhou Dingyan Chem Co.,Ltd [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 86-571-88025800
  • Fax: 86-571-87156470
  • Address: Xiasha 571, 19TH Street E-COMMERCE 4A 601-602 , Jianggan Area hangzhou,ZhejiangChina

138402-11-6 Irbesartan

  • IUPAC NAME-2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one MOLECULAR FORMULA-C25H28N6O MOLAR MASS-428.53
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641870
  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

138402-11-6 Irbesartan

  • Appearance:white or almost white crytalline powder Packing:cardboard drum 25kg/pail Usage: Using compose the medicine of resist hypertension ,using cure the disease of hypertension
  • Min. Order: 1
  • FOB Price: USD1 - 111 /
  • China Hubei Xinzhogrong Pharmaceutical CO.,LTD. [Manufacturer, Trading Company]
  • Tel: 86-0576-88698107
  • Address: The Park of Longgan Huanggan,HubeiChina
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138402-11-6 Irbesartan

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138402-11-6 Irbesartan

  • "Irbesartan MF: C25H28N6O MW: 528.5294 CAS: 138402-11-6 Content:: 99% Characteristics: white crystalline powder Quality standard: Traditional Chinese Medicine Package:25KG/ paperboard barrel Usage: used in the treatment of primary hypertension. Our a...
  • Min. Order: 100
  • FOB Price: USD1 - 1.5 /
  • China Wuhan Xinzekang Chemical Co.,Ltd [Manufacturer]
  • Tel: 86-027-87886092
  • Fax: 86-027-87886092
  • Address: No. 209, Xiongchu Ave,Hongshan District,Wuhan,Hubei,430070, China wuhan,HubeiChina
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138402-11-6 Irbesartan

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
  • Fax: +86 592 2680237
  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
    No.9 Hubin West Rd.,
    Xiamen China. null,nullChina
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138402-11-6 2-ISOPROPRYL-4-METHYLTHIAZOLE

  • Germany Intatrade Chemicals GmbH [Manufacturer]
  • Tel: +49 3493/605464
  • Fax: +49 3493/605470
  • Address: Intatrade Chemicals GmbH
    Vierzoner Strasse 14
    D-06749 Bitterfeld, Germany null,nullGermany
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138402-11-6 IRBESARTAN

  • China Shanghai Sinch Parmaceuticals Tech. Co. Ltd. [Manufacturer]
  • Tel: +86-21-54097791/ +86-13386129050 (mobile)
  • Fax: +86-21-54096319
  • Address: SINCH Pharmaceuticals Tech. Co., Ltd
    Bldg 2, 237 Xitai Rd, Xuhui district,
    Shanghai 200232, China null,nullChina
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138402-11-6 Irbesartan

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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References of 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,
3-diazaspiro[4.4]non-1-en-4-one
Title: Irbesartan
CAS Registry Number: 138402-11-6
CAS Name: 2-Butyl-3-[[2¢-(1H-tetrazol-5-yl)[1,1¢-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Synonyms: 2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one; 2-n-butyl-4-spirocyclopentane-1-[(2¢-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one
Manufacturers' Codes: BMS-186295; SR-47436
Trademarks: Aprovel (Sanofi-Synthelabo); Avapro (Sanofi-Synthelabo)
Molecular Formula: C25H28N6O
Molecular Weight: 428.53
Percent Composition: C 70.07%, H 6.59%, N 19.61%, O 3.73%
Literature References: Angiotensin II type 1 (AII1)-receptor antagonist. Prepn: C. Bernhart et al., WO 9114679; eidem, US 5270317 (1991, 1993 both to Sanofi); eidem et al., J. Med. Chem. 36, 3371 (1993). HPLC determn in plasma and urine: S.-Y. Chang et al., J. Chromatogr. B 702, 149 (1997). Metabolism: T. J. Chando et al., Drug Metab. Dispos. 26, 408 (1998). Review of pharmacology and clinical efficacy: J. C. Gillis, A. Markham, Drugs 54, 885-902 (1997). Renoprotective effect in diabetic nephropathy: E. J. Lewis et al., N. Engl. J. Med. 345, 851 (2001); H.-H. Parving et al., ibid. 870.
Properties: Crystals from 96% ethanol, mp 180-181°.
Melting point: mp 180-181°
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive; Biphenyltetrazole Derivatives.