Home > Name List By other > (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3, 4-dihydro-2H-isoquinoline

CAS No 14009-24-6 , (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,
4-dihydro-2H-isoquinoline

  • Name: (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,
    4-dihydro-2H-isoquinoline
  • Synonyms: drotaverine; Drotin;(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,
    4-dihydro-2H-isoquinoline; Drotaverina [INN-Spanish]; Drotaverine [INN]; Drotaverinum [INN-Latin]; No-Spa; 14009-24-6; dihydroisoperparine;
  • CAS Registry Number:
  • Melting Point: 184 -188ºC
  • Density: 1.097 g/cm3
  • Molecular Weight: 397.50724
  • InchiKey: OMFNSKIUKYOYRG-MOSHPQCFSA-N
  • InChI: InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-
    8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,
    1-4H3/b20-13-
  • Molecular Formula: C24H31NO4
  • Molecular Structure:CAS No:14009-24-6 (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,<br />4-dihydro-2H-isoquinoline
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14009-24-6 DROTAVERINE HYDROCHLORIDE ,=99%

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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14009-24-6 DROTAVERIN HYDROCHLORIDE

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
  • Fax: +86 592 2680237
  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
    No.9 Hubin West Rd.,
    Xiamen China. ,China
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14009-24-6 Drotaverine Hydrochloride

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14009-24-6 Isoquinoline,1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-

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14009-24-6 Isoquinoline,1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-

  • China KINFON PHARMACEUTICAL AND CHEMICAL CO.LTD [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: +86-23-8650081
  • Fax: +86-23-8650081
  • Address: 7F,Commercial Building, No.3 Nanping West Road,Nan ,China
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14009-24-6 Drotaverine HCl

  • China Zibo Boke T&I Co., Ltd. []
  • Tel: +86-533-2362137
  • Fax: 86-533-2362170
  • Address: Zibo City ,Shandong,China ,ShandongChina
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14009-24-6 Drotaverine

  • China Saniver Limited []
  • Fax: +86-21-62882088 +86-852-23333065
  • Address: 805 Harbour Centre, Tower 2, 8 Hok Cheung St., Hunghom, Kowloon, Hong Kong. ,China
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14009-24-6 Drotaverine

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14009-24-6 Drotaverine Hydrochloride

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References of (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,
4-dihydro-2H-isoquinoline
Title: Drotaverine
CAS Registry Number: 14009-24-6
CAS Name: 1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
Synonyms: 1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline; isodihydroperparine
Molecular Formula: C24H31NO4
Molecular Weight: 397.51
Percent Composition: C 72.52%, H 7.86%, N 3.52%, O 16.10%
Literature References: Analogue of papaverine, q.v. Prepn: BE 621917 (1962 to Chinoin), C.A. 59, 8713g (1963). Synthesis: E. Koltai et al., J. Labelled Compd. Radiopharm. 16, 351 (1979). Crystal structure: Z. B?cksei et al., Acta Crystallogr. C51, 1587 (1995). Absorption study: P. Szentmiklosi, S. Marton, Pharmazie 38, 611 (1983). Platelet aggregation and hemorrheological effects: Z. Kapui et al., Thromb. Res. 66, 693 (1992). Clinical pharmacokinetics and bioavailability: O. O. Bolaji et al., Eur. J. Drug Metab. Pharmacokinet. 21, 217 (1996). HPLC determn in biological fluids: eidem, J. Chromatogr. 622, 93 (1993). Clinical evaluation: D. Vecsey, Ther. Hung. 32, 127 (1984). Clinical effects on fetal development: A. E. Czeizel, M. Rockenbauer, Prenatal Neonat. Med. 1, 137 (1996).
 
Derivative Type: Acephyllinate
CAS Registry Number: 61954-97-0
Synonyms: Drotaverine theophylline-7-acetic acid; 6,7,3¢,4¢-tetraethoxy-1-benzyl-3,4-dihydroisoquinoline xanthine-7-acetate; DRA
Trademarks: Depogen (Chinoin)
Molecular Formula: C24H31NO4.C9H10N4O4
Molecular Weight: 635.71
Percent Composition: C 62.35%, H 6.50%, N 11.02%, O 20.13%
Properties: Exists as monohydrate.
 
Derivative Type: Hydrochloride
CAS Registry Number: 985-12-6
Trademarks: No-Spa (Chinoin)
Properties: Pale yellow crystals from ethanol, mp 197-200° (uncorr).
Melting point: mp 197-200° (uncorr)
 
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic.