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CAS No 14028-44-5 , 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine Search by region : Canada

  • Name: 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
  • Synonyms: 14028-44-5;Asendin; Desmethylloxapin; Amoxepine; Amoxapina; Defanyl; Asendis; Demolox; Moxadil;8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 175-1760C
  • Flash Point: 238°C
  • Boiling Point: 469.9°Cat760mmHg
  • Density: 1.37g/cm3
  • Refractive index: 1.685
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 238°C
  • EINECS: 237-867-1
  • Molecular Weight: 313.78144
  • InchiKey: QWGDMFLQWFTERH-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-
    3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
  • Risk Statements: S36
  • Molecular Formula: C17H16ClN3O
  • Molecular Structure:CAS No:14028-44-5 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine

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14028-44-5 AMOXAPINE-D8

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References of 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
Title: Amoxapine
CAS Registry Number: 14028-44-5
CAS Name: 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine
Manufacturers' Codes: CL-67772
Trademarks: Asendin (Lederle); Asendis (Wyeth); Defanyl (Lederle); Demolox (Am. Cyanamid); Moxadil (Lederle)
Molecular Formula: C17H16ClN3O
Molecular Weight: 313.78
Percent Composition: C 65.07%, H 5.14%, Cl 11.30%, N 13.39%, O 5.10%
Literature References: Prepn: J. Schmutz et al., Helv. Chim. Acta 50, 245 (1967); eidem, Chim. Ther. 2, 424 (1967); C. F. Howell et al., FR 1508536; eidem, US 3663696 (1968, 1972 both to Am. Cyanamid). Analysis of amoxapine and its metabolites by GLC: T. B. Cooper, R. G. Kelly, J. Pharm. Sci. 68, 216 (1979). X-ray crystallography: D. B. Cosulich, F. M. Lovell, Acta Crystallogr. B33, 1147 (1977). Pharmacology: E. N. Greenblatt et al., Arch. Int. Pharmacodyn. Ther. 233, 107 (1978). Clinical study: R. Takahashi et al., J. Int. Med. Res. 7, 7 (1979). Review: T. A. Ban, Psychopharmacol. Bull. 15, 22-25 (1979); E. N. Greenblatt et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 1-18. Review of pharmacology and therapeutic efficacy: S. G. Jue et al., Drugs 24, 1-23 (1982).
Properties: Crystals from benzene/petr ether, mp 175-176°. LD50 in mice (mg/kg): 122 i.p.; 112 orally (Howell, 1972).
Melting point: mp 175-176°
Toxicity data: LD50 in mice (mg/kg): 122 i.p.; 112 orally (Howell, 1972)
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.