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CAS No 1977-10-2 , 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine

  • Name: 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
  • Synonyms: Oxilapine; Loxitane IM; Dibenzoazepine;Cloxazepine; Dibenzacepin; Hydrofluoride 3170; Lossapina [DCIT]; Loxapin;8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine;
  • CAS Registry Number:
  • Flash Point: 231.1°C
  • Boiling Point: 458.6°Cat760mmHg
  • Density: 1.31g/cm3
  • Safety Statements: Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Experimental teratogenic and reproductive effects. A tranquilizer. Many dibenz-azepine compounds have central nervous system effects. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Flash Point: 231.1°C
  • EINECS: 217-835-3
  • Molecular Weight: 327.80802
  • InchiKey: XJGVXQDUIWGIRW-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-
    17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
  • Molecular Formula: C18H18ClN3O
  • Molecular Structure:CAS No:1977-10-2 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine

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References of 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
Title: Loxapine
CAS Registry Number: 1977-10-2
CAS Name: 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine
Synonyms: oxilapine
Manufacturers' Codes: CL-62362; S-805; SUM-3170
Molecular Formula: C18H18ClN3O
Molecular Weight: 327.81
Percent Composition: C 65.95%, H 5.53%, Cl 10.82%, N 12.82%, O 4.88%
Literature References: Prepn: NL 6406089; Schmutz et al., US 3546226 (1964, 1970 both to Wander); eidem Helv. Chim. Acta 50, 245 (1967); Coppola, US 3412193 (1968 to Am. Cyanamid). Crystal structure: D. B. Cosulich, F. M. Lovell, Acta Crystallogr. 33B, 1147 (1977). Pharmacology: Schmutz et al., Chim. Ther. 2, 424 (1967); Latimer, J. Pharmacol. Exp. Ther. 166, 151 (1969). Toxicity data: Stille et al., Arzneim.-Forsch. 15, 841 (1965). Toxicity studies: Mineshita et al., Oyo Yakuri 4, 293 (1970), C.A. 76, 81145v (1972). Review of pharmacology and therapeutic efficacy: R. C. Heel et al., Drugs 15, 198-217 (1978).
Properties: Pale yellowish crystals from petr ether, mp 109-110°. LD50 orally in mice: 65 mg/kg (Stille).
Melting point: mp 109-110°
Toxicity data: LD50 orally in mice: 65 mg/kg (Stille)
 
Derivative Type: Succinate
CAS Registry Number: 27833-64-3
Manufacturers' Codes: CL-71563
Trademarks: Loxapac (Eisai); Loxitane (Watson)
Molecular Formula: C18H18ClN3O.C4H6O4
Molecular Weight: 445.90
Percent Composition: C 59.26%, H 5.43%, Cl 7.95%, N 9.42%, O 17.94%
 
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic.