Home > Name List By 4 > 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]pyrimidin-2-one

CAS No 143491-57-0 , 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,
3-oxathiolan-5-yl]pyrimidin-2-one

  • Name: 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,
    3-oxathiolan-5-yl]pyrimidin-2-one
  • Synonyms: 524W91; (-)-FTC; dOTFC;4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,
    3-oxathiolan-5-yl]pyrimidin-2-one; BW-524W91; Emtriva; 143491-57-0;Coviracil; BW524W91; Racivir;
  • CAS Registry Number:
  • Flash Point: 221.9ºC
  • Boiling Point: 443.3ºC at 760 mmHg
  • Density: 1.82 g/cm3
  • Refractive index: 1.731
  • Flash Point: 221.9ºC
  • Molecular Weight: 247.246703
  • InchiKey: XQSPYNMVSIKCOC-NTSWFWBYSA-N
  • InChI: InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,
    13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
  • Molecular Formula: C8H10FN3O3S
  • Molecular Structure:CAS No:143491-57-0 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,<br />3-oxathiolan-5-yl]pyrimidin-2-one

Related products

Search by region :

Select to

143491-57-0 Emtricitabin

  • Emtricitabin
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
Contact Supplier

143491-57-0 Emtricitabine

  • Emtricitabine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

143491-57-0 emtricitabine

  • China Wuxi Mizat Chemical Technology Co., Ltd. [Manufacturer]
  • Tel: +86-510-86106900/ +86-510-86125752
  • Fax: +86-510-86125752
  • Address: No.205,zhencheng Road,
    HI-TECT District,
    Wuxi, Jiangsu,China null,nullChina
Contact Supplier

143491-57-0 Emtricitabine

  • Emtricitabine
  • United States RIA International [Manufacturer]
  • Tel: 19735811282
  • Fax: 19735811283
  • Address: 11 Melanie Lane #17 East Hanover 07936 NJ UNITED STATES NJ,nullUnited States
Contact Supplier

143491-57-0 emtricitabine

Contact Supplier

143491-57-0 Emtricitabine

  • India Triveni Chemicals null
  • Tel: +91-(260)-2400022, 3258683
  • Fax: +91-(260)-2400022/3264008
  • Address: 135, Pancharatna, Char Rasta, G.I.D.C., Vapi, Gujarat 396 195, null,nullIndia
Contact Supplier

143491-57-0 Entricitabine

  • Entricitabine, 99%UP
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
Contact Supplier

143491-57-0 Emtricitabine

  • China Watson International Ltd. null
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, null,nullChina
Contact Supplier

143491-57-0 EMTRICITABINE

  • India JAI RADHE SALES null
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. null,nullIndia
Contact Supplier

143491-57-0 Emtricitabine

Contact Supplier

Select to

2/8
Previous 1 2 3 4 5 6 7 8 Next
References of 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,
3-oxathiolan-5-yl]pyrimidin-2-one
Title: Emtricitabine
CAS Registry Number: 143491-57-0
CAS Name: 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Synonyms: (-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one; (-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; (-)-b-2￠,3￠-dideoxy-5-fluoro-3￠-thiacytidine; (-)-FTC
Manufacturers' Codes: 524W91; BW-524W91
Trademarks: Coviracil (Triangle); Emtriva (Gilead)
Molecular Formula: C8H10FN3O3S
Molecular Weight: 247.25
Percent Composition: C 38.86%, H 4.08%, F 7.68%, N 16.99%, O 19.41%, S 12.97%
Literature References: Reverse transcriptase inhibitor; nucleoside analog structurally related to lamivudine, q.v. Prepn: D. C. Liotta et al., WO 9214743 (1992 to Emory University); G. Dionne, US 5538975 (1996 to BioChem Pharma, Inc.); L. S. Jeong et al., J. Med. Chem. 36, 181 (1993). Absolute configuration: P. van Roey et al., Antiviral Chem. Chemother. 4, 369 (1993). HPLC-NMR determn of urinary metabolites: J. P. Shockcor et al., Xenobiotica 26, 189 (1996). Comparative efficacy of enantiomers vs HIV: R. F. Schinazi et al., Antimicrob. Agents Chemother. 36, 2423 (1992). Pharmacokinetics: L. W. Frick et al., ibid. 38, 2722 (1994). Mechanism of action study: J. Y. Feng et al., FASEB J. 13, 1511 (1999). Clinical study in combination with didanosine and efavirenz: J.-M. Molina et al., J. Infect. Dis. 182, 599 (2000). Review: P. Cahn, Expert Opin. Invest. Drugs 13, 55-68 (2004).
Properties: White solid from ether and methanol, mp 136-140°. [a]D25 -133.60° (c = 0.23 in MeOH). uv max (water): 287.8 nm (pH 2); 280.0 nm (pH 7); 279.8 nm (pH 11) (e 14210, 11090, 11810).
Melting point: mp 136-140°
Optical Rotation: [a]D25 -133.60° (c = 0.23 in MeOH)
Absorption maximum: uv max (water): 287.8 nm (pH 2); 280.0 nm (pH 7); 279.8 nm (pH 11) (e 14210, 11090, 11810)
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones; Reverse Transcriptase Inhibitor.