Home > Name List By 4 > 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]pyrimidin-2-one China

CAS No 143491-57-0 , 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,
3-oxathiolan-5-yl]pyrimidin-2-one Search by region : China

  • Name: 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,
    3-oxathiolan-5-yl]pyrimidin-2-one
  • Synonyms: 524W91; (-)-FTC; dOTFC;4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,
    3-oxathiolan-5-yl]pyrimidin-2-one; BW-524W91; Emtriva; 143491-57-0;Coviracil; BW524W91; Racivir;
  • CAS Registry Number:
  • Flash Point: 221.9ºC
  • Boiling Point: 443.3ºC at 760 mmHg
  • Density: 1.82 g/cm3
  • Refractive index: 1.731
  • Flash Point: 221.9ºC
  • Molecular Weight: 247.246703
  • InchiKey: XQSPYNMVSIKCOC-NTSWFWBYSA-N
  • InChI: InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,
    13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
  • Molecular Formula: C8H10FN3O3S
  • Molecular Structure:CAS No:143491-57-0 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,<br />3-oxathiolan-5-yl]pyrimidin-2-one

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143491-57-0 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1, 3-oxathiolan-5-yl]pyrimidin-2-one

  • CBNumber: CB5266199 Chemical Name: Emtricitabine Molecular Formula: C8H10FN3O3S Formula Weight: 247.25 CAS No.: 143491-57-0
  • FOB Price: RMB1 - 100 /
  • China Wuhu Nowe Chemical Technologies Co,Ltd. [Manufacturer]
  • Tel: 86-0553-8233716
  • Fax: 89-553-2911116
  • Address: Xingduhui Block C,Huangshan East Road, Jinghu Zone Wuhu,AnhuiChina
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143491-57-0 Factory Supply 99% High Purity Emtricitabine with Good Price

  • Product name:Emtricitabine CAS No.:143491-57-0 Molecular formula:C8H10FN3O3S Molecular weight:247.25 Product Specifications:Pharmacopoeial grade Purity:99%+ Email: dahuasales02@whdhwy.com WhatApp/WeChat:+86 15623424115
  • FOB Price: USD0 - 1 /
  • China Wuhan Dahua Weiye Pharmaceutical Devolepment Co.,Ltd [Manufacturer]
  • Tel: 86-027-59262863
  • Fax: 86-027-59262863
  • Address: Daijiashan 45#,Jiangan Economic Development Zone,Wuhan,Hubei,China Wuhan,HubeiChina
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143491-57-0 emtricitabine

  • "Description A white or almost white crystalline powder Identification Conform with spectrum off the reference standard Enantiomer ≤0.50% Related substance 5-Flucytosine ≤0.20% Total impurities ≤1.0% Residual solvents Ethanol ≤0.50% Dichlorometha...
  • China Hangzhou Dingyan Chem Co.,Ltd [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 86-571-88025800
  • Fax: 86-571-87156470
  • Address: Xiasha 571, 19TH Street E-COMMERCE 4A 601-602 , Jianggan Area hangzhou,ZhejiangChina

143491-57-0 emtricitabine

  • China Syntechem Co.,Ltd [Manufacturer]
  • Tel: +86-519-89882658
  • Fax: +86-519-8512 5369
  • Address: Syntechem Co.,Ltd
    18 South Zhulin Rd.
    Tianning district,Changzhou
    Jiangsu China 213022 null,nullChina
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143491-57-0 emtricitabine

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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143491-57-0 Emtricitabine

  • Emtricitabine Emtricitabin Emtritabine Entricitabine (-)-BETA-2',3'-DIDEOXY-5-FLUORO-3'-THIACYTIDINE
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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143491-57-0 Emtricitabine

  • Emtricitabine
  • China Betapharma Shanghai Inc.Co., Ltd [Manufacturer]
  • Tel: 86-21-62951620
  • Fax: 86-21-32230794
  • Address: Jinming Building 12A No. 8 Zunyi(S) Rd. Shanghai China 200336 shanghaiCHINA shanghai,nullChina
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143491-57-0 Emtricitabine

  • Emtricitabine, 97%
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 null,nullChina
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143491-57-0 Emtricitabin

  • Emtricitabin
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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143491-57-0 Emtricitabine

  • Emtricitabine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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References of 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,
3-oxathiolan-5-yl]pyrimidin-2-one
Title: Emtricitabine
CAS Registry Number: 143491-57-0
CAS Name: 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Synonyms: (-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one; (-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; (-)-b-2¢,3¢-dideoxy-5-fluoro-3¢-thiacytidine; (-)-FTC
Manufacturers' Codes: 524W91; BW-524W91
Trademarks: Coviracil (Triangle); Emtriva (Gilead)
Molecular Formula: C8H10FN3O3S
Molecular Weight: 247.25
Percent Composition: C 38.86%, H 4.08%, F 7.68%, N 16.99%, O 19.41%, S 12.97%
Literature References: Reverse transcriptase inhibitor; nucleoside analog structurally related to lamivudine, q.v. Prepn: D. C. Liotta et al., WO 9214743 (1992 to Emory University); G. Dionne, US 5538975 (1996 to BioChem Pharma, Inc.); L. S. Jeong et al., J. Med. Chem. 36, 181 (1993). Absolute configuration: P. van Roey et al., Antiviral Chem. Chemother. 4, 369 (1993). HPLC-NMR determn of urinary metabolites: J. P. Shockcor et al., Xenobiotica 26, 189 (1996). Comparative efficacy of enantiomers vs HIV: R. F. Schinazi et al., Antimicrob. Agents Chemother. 36, 2423 (1992). Pharmacokinetics: L. W. Frick et al., ibid. 38, 2722 (1994). Mechanism of action study: J. Y. Feng et al., FASEB J. 13, 1511 (1999). Clinical study in combination with didanosine and efavirenz: J.-M. Molina et al., J. Infect. Dis. 182, 599 (2000). Review: P. Cahn, Expert Opin. Invest. Drugs 13, 55-68 (2004).
Properties: White solid from ether and methanol, mp 136-140°. [a]D25 -133.60° (c = 0.23 in MeOH). uv max (water): 287.8 nm (pH 2); 280.0 nm (pH 7); 279.8 nm (pH 11) (e 14210, 11090, 11810).
Melting point: mp 136-140°
Optical Rotation: [a]D25 -133.60° (c = 0.23 in MeOH)
Absorption maximum: uv max (water): 287.8 nm (pH 2); 280.0 nm (pH 7); 279.8 nm (pH 11) (e 14210, 11090, 11810)
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones; Reverse Transcriptase Inhibitor.