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CAS No 144510-96-3 , 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione

  • Name: 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione
  • Synonyms: 144510-96-3; 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione; Pixuvri (TN);6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione;
  • CAS Registry Number:
  • Flash Point: 346.9°C
  • Boiling Point: 650°Cat760mmHg
  • Density: 1.405
  • Refractive index: 1.728
  • Flash Point: 346.9°C
  • Molecular Weight: 325.36506
  • InchiKey: PEZPMAYDXJQYRV-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H19N5O2/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-
    6-20-9-11(10)17(15)24/h1-3,6,9,21-22H,4-5,7-8,18-19H2
  • Molecular Formula: C17H19N5O2
  • Molecular Structure:CAS No:144510-96-3 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione
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144510-96-3 Benz[g]isoquinoline-5,10-dione,6,9-bis[(2-aminoethyl)amino]-

  • China Watson International Ltd. null
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, null,nullChina
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144510-96-3 Pixantrone

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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144510-96-3 Benz[g]isoquinoline-5,10-dione,6,9-bis[(2-aminoethyl)amino]-

  • China Wuxi Mizat Chemical Technology Co., Ltd. [Manufacturer]
  • Tel: +86-510-86106900/ +86-510-86125752
  • Fax: +86-510-86125752
  • Address: No.205,zhencheng Road,
    HI-TECT District,
    Wuxi, Jiangsu,China null,nullChina
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144510-96-3 Pixantrone

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
  • Fax: +86-(21)-61094103
  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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144510-96-3 Pixantrone

  • China Taizhou Crene Chempharm Co., Ltd. null
  • Tel: +86-(576)-88813233
  • Fax: +86-(576)-88670057
  • Address: Weiwu Load Economic Developed Zone, Taizhou, Zhejiang 318000, null,nullChina
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144510-96-3 Benz[g]isoquinoline-5,10-dione,6,9-bis[(2-aminoethyl)amino]-

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144510-96-3 Pixantrone

  • China Yongyi Biotechnology Co,.Ltd [Importer/Exporter]
  • Tel: +86-21-60904639
  • Fax: +86-21-60904609
  • Address: Suite 3005, City Gateway, No.398 North CaoXi Road, XuHui District, Shanghai 200030, China. null,nullChina
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144510-96-3 Pixantrone

  • China Shanghai Boyle Chemical Co., Ltd. [Manufacturers]
  • Tel: +86-(21)-6846-5680,50185988
  • Fax: +86-(21)-50185998
  • Address: Room 520-522, No.135, Dongfang Road, Pudong New District, Shanghai, Shanghai 200120, Shanghai,ShanghaiChina
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144510-96-3 Benz[g]isoquinoline-5,10-dione,6,9-bis[(2-aminoethyl)amino]-

  • China shangchem [Manufacturers]
  • Tel: +86-21-68182121
  • Fax: +86-21-68182121
  • Address: zhangjiang Hi-tech pudong shanghai null,shanghaiChina
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144510-96-3 Benz[g]isoquinoline-5,10-dione,6,9-bis[(2-aminoethyl)amino]-

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References of 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione
Title: Pixantrone
CAS Registry Number: 144510-96-3
CAS Name: 6,9-Bis[(2-aminoethyl)amino]benz[g]isoquinoline-5,10-dione
Molecular Formula: C17H19N5O2
Molecular Weight: 325.37
Percent Composition: C 62.75%, H 5.89%, N 21.52%, O 9.83%
Literature References: Second generation aza-anthracenedione analog which intercalates DNA and inhibits topoisomerase II; structurally similar to mitoxantrone, q.v. Prepn: P. A. Krapcho, EP 503537 (1992 to Univ. of Vermont); idem et al., J. Med. Chem. 37, 828 (1994). Solid-state characterization: A. Marini et al., J. Pharm. Sci. 92, 577 (2003). Antitumor spectrum and evaluation of cardiotoxic potential: G. Beggiolin et al., Tumori 87, 407 (2001). Immunosuppressant activity: G. Cavaletti et al., J. Neuroimmunol. 151, 55 (2004). Clinical pharmacokinetics: S. Faivre et al., Clin. Cancer Res. 7, 43 (2001). Clinical evaluation in non-Hodgkin's lymphoma: P. Borchmann et al., Haematologica 88, 888 (2003). Review of development and therapeutic potential: P. Borchmann, R. Schnell, Expert Opin. Invest. Drugs 14, 1055-1061 (2005).
 
Derivative Type: Dimalate salt
CAS Registry Number: 144675-97-8
Manufacturers' Codes: BBR-2778
Molecular Formula: C17H19N5O2.2C4H14O4
Molecular Weight: 577.67
Percent Composition: C 51.98%, H 8.20%, N 12.12%, O 27.70%
Properties: Blue solid from ethanol and ether, mp 192° (dec). Moderately sol in physiological saline.
Melting point: mp 192°
 
Derivative Type: Hydrochloride
CAS Registry Number: 175989-38-5
Molecular Formula: C17H19N5O2.HCl
Molecular Weight: 361.83
Percent Composition: C 56.43%, H 5.57%, N 19.36%, O 8.84%, Cl 9.80%
Properties: Dark blue hygroscopic solid from chloroform, mp 209-212°.
Melting point: mp 209-212°
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Topoisomerase II Inhibitor.