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CAS No 145158-71-0 , 1-[[(Z)-(5-methoxyindol-3-ylidene)methyl]amino]-2-pentylguanidine

  • Name: 1-[[(Z)-(5-methoxyindol-3-ylidene)methyl]amino]-2-pentylguanidine
  • Synonyms: NCGC00095192-01;AC1NSFYX;1-[[(Z)-(5-methoxyindol-3-ylidene)methyl]amino]-2-pentylguanidine; Spectrum_001950; Spectrum3_001855; Spectrum2_001100; Spectrum4_000730; Tegaserod (USAN/INN); Spectrum5_001691;
  • CAS Registry Number:
  • Transport: HAZARD
  • Melting Point: 188-190ºC
  • Density: 1.18
  • Safety Statements: R20/21/22
  • Hazard Symbols: UN NO.
  • Molecular Weight: 301.38672
  • InchiKey: JWXDRFUZDKKGDV-VAWYXSNFSA-N
  • InChI: InChI=1S/C16H23N5O/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)
    9-14(12)15/h6-7,9-11,20H,3-5,8H2,1-2H3,(H3,17,18,21)/b12-11+
  • Risk Statements: S36/37
  • Molecular Formula: C16H23N5O
  • Molecular Structure:CAS No:145158-71-0 1-[[(Z)-(5-methoxyindol-3-ylidene)methyl]amino]-2-pentylguanidine

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References of 1-[[(Z)-(5-methoxyindol-3-ylidene)methyl]amino]-2-pentylguanidine
Title: Tegaserod
CAS Registry Number: 145158-71-0
CAS Name: 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide
Molecular Formula: C16H23N5O
Molecular Weight: 301.39
Percent Composition: C 63.76%, H 7.69%, N 23.24%, O 5.31%
Literature References: Selective serotonin 5HT4-receptor partial agonist. Prepn: R. K. A. Giger, H. Mattes, EP 505322; eidem, US 5510353 (1992, 1996 both to Sandoz); K.-H. Buchheit et al., J. Med. Chem. 38, 2331 (1995). Clinical pharmacology: S. Appel et al., Clin. Pharmacol. Ther. 62, 546 (1997); and pharmacokinetics: idem et al., J. Clin. Pharmacol. 37, 229 (1997). Clinical trial in irritable bowel syndrome: S. A. Müller-Lissner et al., Aliment. Pharmacol. Ther. 15, 1655 (2001); in female patients: J. Novick et al., ibid. 16, 1877 (2002). Review of clinical efficacy: B. W. Jones et al., J. Clin. Pharm. Ther. 27, 343-352 (2002); of mechanism of action, efficacy and safety: M. Corsetti, J. Tack, Expert Opin. Pharmacother. 3, 1211-1218 (2002).
Properties: mp 155°.
Melting point: mp 155°
 
Derivative Type: Maleate
CAS Registry Number: 189188-57-6
Manufacturers' Codes: SDZ-HTF-919
Trademarks: Zelmac (Novartis); Zelnorm (Novartis)
Molecular Formula: C16H23N5O.C4H4O4
Molecular Weight: 417.46
Percent Composition: C 57.54%, H 6.52%, N 16.78%, O 19.16%
 
Therap-Cat: Gastroprokinetic; in treatment of irritable bowel syndrome.
Keywords: Gastroprokinetic; Serotonin Receptor Agonist.