CAS No 1491-59-4 , 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol Search by region : India

Name: 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
Synonyms: Sinerol; Navisin; Oxylazine; Rhinofrenol; Oximetazolinum; Hazol;Oxymethazoline;6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol; Nafrine; Iliadin;
CAS Registry Number:1491-59-4
Transport: 3249
Melting Point: 182 ºC
Density: 1.08 g/cm³
Safety Statements: Poison by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
EINECS: 216-079-1
Molecular Weight: 260.37456
InchiKey: WYWIFABBXFUGLM-UHFFFAOYSA-N
InChI: InChI=1S/C16H24N2O/c1-10-8-13(16(3,
4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
Molecular Formula: C₁₆H₂₄N₂O
Molecular Structure:

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           1491-59-4 oxymetazoline
           IUPAC NAME-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)- 2,4-dimethyl-6-tert-butyl-phenol MOLECULAR FORMULA-C16H24N2O MOLAR MASS-260.375?g·mol?1 xymetazoline is a selective alpha-1 agonist and partial alpha-2 agonist topical decongestant
 
             Swapnroop Drugs and Pharmaceuticals
             
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           1491-59-4 OXYMETAZOLINE-D4
           
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           1491-59-4 OXYMETAZOLINE 
           
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           1491-59-4 Oxymetazoline
           
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References of 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol

Title: Oxymetazoline
CAS Registry Number: 1491-59-4
CAS Name: 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol
Synonyms: 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol; 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline
Manufacturers' Codes: H-990
Trademarks: Navisin; Hazol; Rhinofrenol; Rhinolitan (3M Pharma); Sinerol; Nezeril (Draco)
Molecular Formula: C16H24N2O
Molecular Weight: 260.37
Percent Composition: C 73.81%, H 9.29%, N 10.76%, O 6.14%
Literature References: Prepd from (4-tert-butyl-2,6-dimethyl-3-hydroxyphenyl)acetonitrile and ethylenediamine: Fruhstorfer, Mueller-Calgan, DE 1117588 (1961 to E. Merck), C.A. 57, 4674a (1962). Toxicity data: Hotovy et al., Arzneim.-Forsch. 11, 1016 (1961).
Properties: Crystals from benzene, mp 181-183°.
Melting point: mp 181-183°

Derivative Type: Hydrochloride
CAS Registry Number: 2315-02-8
Trademarks: Afrazine (Schering-Plough); Afrin (Schering-Plough); Iliadin (Meda); Nafrine; Nasivin (Merck KGaA); Oxilin (Allergan); Sinex (LaChartre)
Molecular Formula: C16H24N2O.HCl
Molecular Weight: 296.84
Percent Composition: C 64.74%, H 8.49%, N 9.44%, O 5.39%, Cl 11.94%
Properties: Crystals, dec 300-303°. Freely sol in water, alcohol. Practically insol in ether, chloroform, benzene. LD50 orally in mice: 10 mg/kg (Hotovy).
Toxicity data: LD50 orally in mice: 10 mg/kg (Hotovy)

NOTE: Ingredient of Drixin.
Therap-Cat: Adrenergic (vasoconstrictor); nasal decongestant.
Keywords: a-Adrenergic Agonist; Decongestant.