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CAS No 152-97-6 , Fluocortolone

  • Name: Fluocortolone
  • Synonyms: (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6-Fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one; methylfluorodehydrocorticosterone;Fluocortolone;6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione;
  • CAS Registry Number:
  • Flash Point: 278.8°C
  • Boiling Point: 537.4°Cat760mmHg
  • Density: 1.25g/cm3
  • Refractive index: 1.571
  • Safety Statements: An experimental teratogen. Experimental reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F.
  • Flash Point: 278.8°C
  • EINECS: 205-811-5
  • Molecular Weight: 376.47
  • InChI: InChI=1/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1
  • Molecular Formula: C22H29FO4
  • Molecular Structure:CAS No:152-97-6 Fluocortolone
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152-97-6 FLUOCORTOLONE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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152-97-6 Fluocortolone

  • Fluocortolone 152-97-6 B162740
  • China bepharm ltd. []
  • Tel: 86-21-51816456
  • Address: 128 Xiangyin Road, Room C320-321 Yangpu District, Shanghai 200433, China ,China
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152-97-6 FLUOCORTOLONE

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152-97-6 Fluocortolone

  • China Ningbo Inno Pharmchem Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-87319282
  • Fax: +86-(574)-56877908
  • Address: 5F, Building 4, 1035 Guangxian Rd., Ningbo Hi-Tech Park, Ningbo, Zhejiang 315040, Ningbo,ZhejiangChina
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152-97-6 Fluocortolone

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152-97-6 Tiformin, 99%

  • Tiformin, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,China
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152-97-6 fluocortolone

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152-97-6 FLUOCORTOLONE

  • China Guangzhou Topwork Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-20-87317062/ +86-20-87317092
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  • Address: Guangzhou Topwork Chemical Co., Ltd.
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152-97-6 fluocortolone

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References of Fluocortolone
Title: Fluocortolone
CAS Registry Number: 152-97-6
CAS Name: (6a,11b,16a)-6-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 6a-fluoro-16a-methyl-1-dehydrocorticosterone; 6a-fluoro-16a-methyl-D1,4-pregnadiene-11b,21-diol-3,20-dione
Trademarks: Ultralan oral (Schering AG)
Molecular Formula: C22H29FO4
Molecular Weight: 376.46
Percent Composition: C 70.19%, H 7.76%, F 5.05%, O 17.00%
Literature References: Prepn: BE 614196; Kieslich et al., US 3232839 (1962, 1966 to Schering AG); Doménico et al., Arzneim.-Forsch. 15, 46 (1965); Kieslich et al., Ann. 726, 168 (1969). Pharmacology: Doménico et al., loc. cit; Gillich et al., Int. Z. Klin. Pharmakol. Ther. Toxikol. 1, 197 (1968); Von Schoening et al., Klin. Wochenschr. 48, 1448 (1970). Metabolism: Gerhards et al., Acta Endocrinol. 68, 98 (1971). Clinical studies: Breuer et al., Arzneim.-Forsch. 15, 50 (1965).
Properties: Crystals, mp 188-190.5°. Soly (mg/l): 295 in water (37°); 120 in ethanol (20°); 440 in toluene (20°). [a]D20 +100° (dioxane). uv max (methanol): 242 nm (e 16300).
Melting point: mp 188-190.5°
Optical Rotation: [a]D20 +100° (dioxane)
Absorption maximum: uv max (methanol): 242 nm (e 16300)
 
Derivative Type: 21-Acetate
Molecular Formula: C24H31FO5
Molecular Weight: 418.50
Percent Composition: C 68.88%, H 7.47%, F 4.54%, O 19.12%
Properties: Crystals, mp 237-239°. uv max (methanol): 240 nm (e 15860).
Melting point: mp 237-239°
Absorption maximum: uv max (methanol): 240 nm (e 15860)
 
Derivative Type: 21-Hexanoate
CAS Registry Number: 303-40-2
Synonyms: Fluocortolone 21-caproate
Manufacturers' Codes: SH-770
Trademarks: Ficoid (Fisons); Ultralanum (Schering AG)
Molecular Formula: C28H39FO5
Molecular Weight: 474.60
Percent Composition: C 70.86%, H 8.28%, F 4.00%, O 16.86%
Properties: Crystals, mp 242-245°. [a]D20 +98.5° (dioxane). uv max (methanol): 242 nm (e 16200). Soly (mg/l): 7.8 in water (37°); 450 in ethanol (20°); 440 in toluene (20°).
Melting point: mp 242-245°
Optical Rotation: [a]D20 +98.5° (dioxane)
Absorption maximum: uv max (methanol): 242 nm (e 16200)
 
Derivative Type: 21-Pivalate
Synonyms: Fluocortolone trimethylacetate
Molecular Formula: C22H37FO5
Molecular Weight: 400.52
Percent Composition: C 65.97%, H 9.31%, F 4.74%, O 19.97%
Properties: Crystals, mp 187°. Almost insol in water. Sol in chloroform, methanol. Slightly sol in ether.
Melting point: mp 187°
 
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.