Home > Name List By other > (6R, 7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CAS No 153-61-7 , (6R,
7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Name: (6R,
    7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-
    azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Synonyms: Coaxin; Cephalothinum; Keflin; Seffin; Averon-1; Cefalothin;Cefalotin; Cephalotin; Cemastin;(6R,
    7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-
    azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
  • CAS Registry Number:
  • Melting Point: 160-161 ºC
  • Density: 1.56 g/cm3
  • Refractive index: 1.675
  • Water Solubility: 158 MG/L
  • Safety Statements: Poison by parenteral and intracerebral routes. Moderately toxic by intravenous route. Mildly toxic by subcutaneous and intraperitoneal routes. An experimental teratogen. Mutation data reported. See also ESTERS. When heated to decomposition it emits very toxic fumes of NOx and SOx.
  • EINECS: 205-815-7
  • Molecular Weight: 396.43804
  • InchiKey: XIURVHNZVLADCM-IUODEOHRSA-N
  • InChI: InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)
    23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,
    23)/t12-,15-/m1/s1
  • Molecular Formula: C16H16N2O6S2
  • Molecular Structure:CAS No:153-61-7 (6R,<br />7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-<br />azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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153-61-7 Cephalothin, free base

  • Cephalothin, free base
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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153-61-7 CEPHALOSPORIN

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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153-61-7 (6R,7R)-3-(ACETOXYMETHYL)-8-OXO-7-(2-(THIOPHEN-2-YL)ACETAMIDO)-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China ,China
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153-61-7 Cephalothin

  • China Trust&We Co., Ltd. [Manufacturer]
  • Tel: +86-21-61044582
  • Fax: +86-21-61044583
  • Address: 1-102,No.11,Dongjiaominxiang Alley,
    Dongcheng District,
    Beijing 100005,China ,China
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153-61-7 Cephalothin

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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153-61-7 Cephalothin

  • China China Langchem Inc. []
  • Tel: +86-(21)-58956006
  • Fax: +86-(21)-58956100
  • Address: 514 Room, 1# Building, 88# Cailun Road, Zhangjiang High Tech Park, Shanghai 201203, ,China
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153-61-7 Cephalothin

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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153-61-7 Cephalothin

  • China Watson International Ltd. []
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, ,China
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153-61-7 CEPHALOTHIN

  • India JAI RADHE SALES []
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
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153-61-7 Cefalotin

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References of (6R,
7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-
azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Title: Cephalothin
CAS Registry Number: 153-61-7
CAS Name: (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: 3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid acetate; 7-(2-thienylacetamido)cephalosporanic acid; 7-(thiophene-2-acetamido)cephalosporanic acid
Molecular Formula: C16H16N2O6S2
Molecular Weight: 396.44
Percent Composition: C 48.47%, H 4.07%, N 7.07%, O 24.21%, S 16.18%
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: Chauvette et al., J. Am. Chem. Soc. 84, 3401 (1962); E. H. Flynn, US 3218318 (1965 to Lilly); FR 1384197 (1965 to Glaxo), C.A. 63, 11591c (1965). Bacteriology and pharmacology: Lee, Anderson, Antimicrob. Agents Chemother. 1962, 695; Walters et al., ibid. 706; Naumann, Arzneim.-Forsch. 16, 1099 (1966). Acute toxicity: M. Kuramoto et al., Jpn. J. Antibiot. 27, 746 (1974), C.A. 83, 71972t (1975). Comprehensive description: R. J. Simmons, Anal. Profiles Drug Subs. 1, 319-341 (1972).
Properties: mp 160-160.5°. [a]D20 +50° (c = 1.03 in acetonitrile), see R. B. Woodward et al., J. Am. Chem. Soc. 88, 852 (1966).
Melting point: mp 160-160.5°
Optical Rotation: [a]D20 +50° (c = 1.03 in acetonitrile)
 
Derivative Type: Sodium salt
CAS Registry Number: 58-71-9
Trademarks: Averon-1 (Alfar); Cefalotin; Cemastin (Ist. Vitamine); Cephation (Meiji); Ceporacin (Torii); Cepovenin (Hoechst; Glaxo); Chephalotin (Lilly); Coaxin (Tobishi); Keflin (Lilly); Lospoven (Hoechst); Synclotin (Toyo Jozo); Toricelocin (Torii)
Molecular Formula: C16H15N2NaO6S2
Molecular Weight: 418.42
Percent Composition: C 45.93%, H 3.61%, N 6.70%, Na 5.49%, O 22.94%, S 15.33%
Properties: mp 204-205°. [a]D +135° (c = 1.0 in water). uv max: 236, 260 nm (e 12950, 9350). LD50 in mice, rats (mg/kg): >20000, >10000 orally; 5670, 7716 i.p. (Kuramoto).
Melting point: mp 204-205°
Optical Rotation: [a]D +135° (c = 1.0 in water)
Absorption maximum: uv max: 236, 260 nm (e 12950, 9350)
Toxicity data: LD50 in mice, rats (mg/kg): >20000, >10000 orally; 5670, 7716 i.p. (Kuramoto)
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.