Home > Name List By 1 > 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1, 3-thiazol-4-yl)methyl]carbamoy...

CAS No 155213-67-5 , 1,3-thiazol-5-ylmethyl
N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,
3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,
6-diphenylhexan-2-yl]carbamate

  • Name: 1,3-thiazol-5-ylmethyl
    N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,
    3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,
    6-diphenylhexan-2-yl]carbamate
  • Synonyms: A-84538; ABT-538;Norvir; 155213-67-5; Abbott 84538; Ritonavir [USAN]; Norvir (TM); Norvir Sec; 1hxw;1,3-thiazol-5-ylmethyl
    N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,
    3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,
    6-diphenylhexan-2-yl]carbamate;
  • CAS Registry Number:
  • Density: 1.239 g/cm3
  • Refractive index: 1.599
  • Safety Statements: S26;S37/39;
  • Hazard Symbols: Xi
  • Molecular Weight: 720.94422
  • InchiKey: NCDNCNXCDXHOMX-XGKFQTDJSA-N
  • InChI: InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25
    (3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-
    27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,
    20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
  • Risk Statements: 36/38
  • Molecular Formula: C37H48N6O5S2
  • Molecular Structure:CAS No:155213-67-5 1,3-thiazol-5-ylmethyl<br />N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,<br />3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,<br />6-diphenylhexan-2-yl]carbamate

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References of 1,3-thiazol-5-ylmethyl
N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,
3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,
6-diphenylhexan-2-yl]carbamate
Title: Ritonavir
CAS Registry Number: 155213-67-5
CAS Name: (5S,8S,10S,11S)-10-Hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid 5-thiazolylmethyl ester
Synonyms: (2S,3S,5S)-5-[N-[N-[[N-methyl-N-[(2-isopropyl-4-thiazolyl)methyl]amino]carbonyl]valinyl]amino]-2-[N-[(5-thiazolyl)methoxycarbonyl]amino]-1,6-diphenyl-3-hydroxyhexane
Manufacturers' Codes: A-84538; Abbott 84538; ABT-538
Trademarks: Norvir (Abbott)
Molecular Formula: C37H48N6O5S2
Molecular Weight: 720.94
Percent Composition: C 61.64%, H 6.71%, N 11.66%, O 11.10%, S 8.90%
Literature References: Peptidomimetic HIV-1 protease inhibitor. Prepn: D. J. Kempf et al., WO 9414436; eidem, US 5541206 (1994, 1996 both to Abbott). Antiretroviral spectrum, pharmacokinetics: idem et al., Proc. Natl. Acad. Sci. USA 92, 2484 (1995). Structural model for drug resistance: M. Markowitz et al., J. Virol. 69, 701 (1995). HPLC determn in biological fluids: R. M. W. Hoetelmans et al., J. Chromatogr. B 705, 119 (1998). Review of clinical experience: A. P. Lea, D. Faulds, Drugs 52, 541-546 (1996). Clinical trial with nucleoside analogs in HIV-infected children: S. A. Nachman et al., J. Am. Med. Assoc. 283, 492 (2000). Clinical trial with lopinavir, q.v., in HIV infection: S. Walmsley et al., N. Engl. J. Med. 346, 2039 (2002).
Therap-Cat: Antiviral.
Keywords: Antiviral; Peptidomimetics; HIV Protease Inhibitor.