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CAS No 15663-27-1 , Cisplatin

  • Name: Cisplatin
  • Synonyms: cis-Platinum(II) diammine chloride; cis-Diammineplatinum(II) dichloride;cis-DDP; cis-Diamminedichloroplatinum(II);Cisplatin; Platinumdiamminechloride; cis-Dichlorodiammineplatinum(II); Cisplatin;cis-Diaminedichloroplatinum(II); cis-platinum(ii)diammine dichloride; DichlorodiammineplatinumIIyelloworangextl;
  • CAS Registry Number:
  • Transport: UN 1851/3288
  • Melting Point: 270 ºC
  • Density: 3.7
  • Water Solubility: <0.1 G/100 ML AT 19 ºC
  • Safety Statements: R45;R25;R41
  • Hazard Symbols: T: Toxic;
  • EINECS: 239-733-8
  • Molecular Weight: 300.05
  • InChI: InChI=1/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
  • Risk Statements: S53;S26;S39;S45
  • Molecular Formula: Cl2H6N2Pt
  • Molecular Structure:CAS No:15663-27-1 Cisplatin
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15663-27-1 Cisplatin

15663-27-1 Cisplatin

  • Cisplatin Cisplatin(CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts. Target: /products Product Links: http://www.medchemexpress.cn/cisplatin.html Permanent link: http://www.medchemexpress.com/c...
  • United States MedChemexpress LLC [Manufacturer]
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15663-27-1 Cisplatin

  • "Appearance Yellow crystalline powder Identification 1. HPLC: the retention time of the major peak corresponds to that of the standard sample 2. IR: the infrared absorption time spectrum exhibits maximum only at the same wavelengths as that of the st...
  • China Hangzhou Dingyan Chem Co.,Ltd [Manufacturer, Trading Company, Distributor/Wholesaler]
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  • Address: Xiasha 571, 19TH Street E-COMMERCE 4A 601-602 , Jianggan Area hangzhou,ZhejiangChina

15663-27-1 Cisplatin

  • China Chemrio International Limited [Manufacturer]
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  • Address: Chemrio International Limited
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15663-27-1 100112 CIS-DIAMINE PLATINUM-(II)-DICHLORIDE CISPLATIN

  • Germany chemcube UG [Manufacturer]
  • Tel: +49 (22 08) 7 75 04 06
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15663-27-1 Cisplatin

  • Cisplatin Antineoplastic Agents cas:15663-27-1
  • China Jinan Jinghai Chemical Co.,Ltd. [Manufacturer, Trading Company]
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15663-27-1 cis-Dichlorodiamineplatinum(II)

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15663-27-1 Cis-DichlorodiamminePlatinum (II)

  • China Trust&We Co., Ltd. [Manufacturer]
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15663-27-1 Cisplatin

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
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  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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15663-27-1 cis-Dichlorodiamineplatinum(II)

  • China Taiyuan RHF CO., ltd. [Manufacturers]
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References of Cisplatin
Title: Cisplatin
CAS Registry Number: 15663-27-1
CAS Name: (SP-4-2)-Diamminedichloroplatinum
Synonyms: cis-diamminedichloroplatinum; cis-platinum II; cis-DDP; CACP; CPDC; DDP
Manufacturers' Codes: NSC-119875
Trademarks: Briplatin (BMS); Cismaplat (Mack, Illert.); Cisplatyl (Bellon); Citoplatino (Rh>e-Poulenc); Lederplatin (Lederle); Neoplatin (BMS); Platamine (Montedison); Platinex (BMS); Platiblastin (Farmitalia); Platinol (BMS); Platinoxan (Degussa); Platistin (Farmitalia); Platosin (Pharmachemie); Randa (Nippon Kayaku)
Molecular Formula: Cl2H6N2Pt
Molecular Weight: 300.05
Percent Composition: Cl 23.63%, H 2.02%, N 9.34%, Pt 65.02%
Literature References: Prepn: M. Peyrone, Ann. 51, 1 (1845); G. B. Kauffman, D. O. Cowan, Inorg. Synth. 7, 239 (1963); S. C. Dhara, Indian J. Chem. 8, 193 (1970). Originally known as Peyrone's salt or Peyrone's chloride, it was primarily of interest in the development of coordination theory. Early structural studies: R. Werner, Z. Anorg. Chem. 3, 267 (1893); H. D. K. Drew et al., J. Chem. Soc. 1932, 988. Discovery of anti-tumor activity: B. Rosenberg et al., Nature 205, 698 (1965); 222, 385 (1972). Use as neoplasm inhibitor: M. L. Tobe et al., DE 2318020 (1972 to Rustenburg Platinum Mines Ltd.), C.A. 80, 55897e (1974); M. J. Cleare et al., DE 2329485 (1972 to Research Corp.), C.A. 81, 21172v (1974). Mechanism of action: J. J. Roberts, J. M. Pascoe, Nature 235, 282 (1972); A. Khan, J. M. Hill, Transplant 13, 55 (1972); G. L. Cohen et al., Science 203, 1014 (1979). X-ray structure of cisplatin-DNA adduct: S. E. Sherman et al., Science 230, 412 (1985). Inhibition of in vitro DNA synthesis: A. L. Pinto, S. J. Lippard, Proc. Natl. Acad. Sci. USA 82, 4616 (1985). Pharmacology: A. Sirica et al., Proc. Am. Assoc. Cancer Res. 12, 4 (1971); C. L. Litterst et al., Cancer Res. 36, 2340 (1976); N. P. Johnson et al., Chem. Biol. Interact. 23, 267 (1978). Metabolism: R. C. Lange et al., J. Nucl. Med. 14, 191 (1973). Clinical studies: J. J. Ochs et al., Cancer Treat. Rep. 62, 239 (1978); H. M. Pinedo et al., Eur. J. Cancer 14, 1149 (1978). Cisplatin has been shown to have trypanocidal effects: M. S. Wysor et al., Science 217, 454 (1982). Toxicology: R. L. Dixon, Proc. 7th Int. Congr. Chemother. Vol. 2 (University Park Press, Baltimore, 1972) pp 241-243; R. W. Fleishman et al., Toxicol. Appl. Pharmacol. 33, 320 (1975). Reviews: D. D. Von Hoff, M. Rozencweig in Advances in Pharmacology and Chemotherapy vol. 16, S. Garattini et al., Eds. (Academic Press, New York, 1979) pp 273-294; S. J. Lippard, Science 218, 1075-1082 (1982). Review of carcinogenicity studies: IARC Monographs 26, 154-161 (1981); of neurotoxicity: R. J. Cersosimo, Cancer Treat. Rev. 16, 195-211 (1989). Comprehensive description: C. M. Riley, L. M. Sternson, Anal. Profiles Drug Subs. 14, 77-105 (1985). Book: Cisplatin, Current Status and New Developments, A. W. Prestayko et al., Eds. (Academic Press, New York, 1980) 527 pp.
Properties: Deep yellow solid, dec 270°. Soly in water 0.253 g/100 g at 25°; slowly changes to trans-form in aq soln. Insol in most common solvents. Sol in DMF. LD50 in guinea pigs: 9.7 mg/kg i.p. (Fleishman).
Toxicity data: LD50 in guinea pigs: 9.7 mg/kg i.p. (Fleishman)
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-67.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Platinum Complexes.