Home > Name List By other > (3S,4aS,8aS)-N-tert-butyl-2-[(2R, 3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4- phenylsulfanylbutyl]-3,4,4a,5,6,7,8, ...

CAS No 159989-64-7 , (3S,4aS,8aS)-N-tert-butyl-2-[(2R,
3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-
phenylsulfanylbutyl]-3,4,4a,5,6,7,8,
8a-octahydro-1H-isoquinoline-3-carboxamide

  • Name: (3S,4aS,8aS)-N-tert-butyl-2-[(2R,
    3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-
    phenylsulfanylbutyl]-3,4,4a,5,6,7,8,
    8a-octahydro-1H-isoquinoline-3-carboxamide
  • Synonyms: VRX496; 1ohr; Nelfinavir Monomethane Sulfonate; Viracept (TN);159989-64-7; Nelfinavir [BAN:INN]; Nelfinavir (INN);(3S,4aS,8aS)-N-tert-butyl-2-[(2R,
    3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-
    phenylsulfanylbutyl]-3,4,4a,5,6,7,8,
    8a-octahydro-1H-isoquinoline-3-carboxamide; AG1343;
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 567.782
  • Flash Point: 429.7°C
  • Boiling Point: 786.8°C at 760 mmHg
  • Density: 1.22g/cm3
  • Refractive index: 1.618
  • Water Solubility: Insoluble (soluble in lower alcohol)
  • Hazard Symbols: UN NO.
  • Flash Point: 429.7°C
  • Molecular Weight: 567.7824
  • InchiKey: QAGYKUNXZHXKMR-HKWSIXNMSA-N
  • InChI: InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-
    6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,
    3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,
    38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1
  • Molecular Formula: C32H45N3O4S
  • Molecular Structure:CAS No:159989-64-7 (3S,4aS,8aS)-N-tert-butyl-2-[(2R,<br />3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-<br />phenylsulfanylbutyl]-3,4,4a,5,6,7,8,<br />8a-octahydro-1H-isoquinoline-3-carboxamide
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159989-64-7 Nelfinavir

  • An HIV-1 protease inhibitor. It inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.https://www.bocsci.com/nelfinavir-cas-159989-64-7-item-84-455040.html
  • Min. Order: 10
  • United States BOC Sciences [Manufacturer]
  • Tel: 1-631-6197922
  • Fax: 1-631-6147828
  • Address: 45-16 Ramsey Road Shirley New York,New YorkUnited States
Contact Supplier

159989-64-7 Nelfinavir

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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159989-64-7 NELFINAVIR

  • United States Carbocore, Inc. [Manufacturer]
  • Tel: 281-367-6833
  • Fax: 281-419-4974
  • Address: Carbocore, Inc.
    P.O. Box 131508
    The Woodlands, TX
    77393-1508 USA ,United States
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159989-64-7 Nelfinavir

  • India Triveni Chemicals []
  • Tel: +91-(260)-2400022, 3258683
  • Fax: +91-(260)-2400022/3264008
  • Address: 135, Pancharatna, Char Rasta, G.I.D.C., Vapi, Gujarat 396 195, ,India
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159989-64-7 3-Isoquinolinecarboxamide,N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-,(3S,4aS,8aS)-

  • China Hangzhou Starshine Pharmaceutical Co., LTD [Manufacturers]
  • Tel: +86-571-89939756 85122191
  • Fax: +86-571-85122157
  • Address: ROOM A, 20 TH FLOOR, WEST BUILDING, INTERNATIONAL GARDEN, NO.160 TIANMUSHAN ROAD, HANGZHOU, CHINA ,ZhejiangChina
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159989-64-7 NELFINAVIR

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
    H4P 2R2 ,Canada
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159989-64-7 Nelfinavir

  • China Huei-Ho International Co., Ltd. [Importer/Exporter]
  • Tel: +86-(21)-6273-7219, 6273-6279
  • Fax: +86-(21)-6129-4387, 62735948
  • Address: 20B,No.2,Lane 600,Peakway Tower,Tianshan Road, Shanghai, shanghai 200051, ,ShanghaiChina
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159989-64-7 Nelfinavir

  • China Shanghai Richem International Co., Ltd. []
  • Tel: +86-(21)-31263688
  • Fax: +86-(21)-51862199
  • Address: Room 603, Golden Eagle Mansion A, No.1518 Minsheng Road, Pudong, Shanghai 200135, shanghai,shanghaiChina
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159989-64-7 Nelfinavir

  • India Exim-Pharm International []
  • Tel: +91-(22)-26191948
  • Fax: +91-(22)-26191948
  • Address: 1, Ashish Mahal, 2nd Floor, Ist Road, Golibar Santacruz (E), Mumbai, Maharashtra 400 055, ,India
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References of (3S,4aS,8aS)-N-tert-butyl-2-[(2R,
3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-
phenylsulfanylbutyl]-3,4,4a,5,6,7,8,
8a-octahydro-1H-isoquinoline-3-carboxamide
Title: Nelfinavir
CAS Registry Number: 159989-64-7
CAS Name: (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide
Synonyms: [3S-(3R*,4aR*,8aR*,2¢S*,3¢S*)]-2-[2¢-hydroxy-3¢-phenylthiomethyl-4¢-aza-5¢-oxo-5¢-(2¢¢-methyl-3¢¢-hydroxyphenyl)pentyl]decahydroisoquinoline-3-N-t-butylcarboxamide
Manufacturers' Codes: AG-1346
Molecular Formula: C32H45N3O4S
Molecular Weight: 567.78
Percent Composition: C 67.69%, H 7.99%, N 7.40%, O 11.27%, S 5.65%
Literature References: HIV protease inhibitor. Prepn: B. A. Dressman et al., WO 9509843; eidem, US 5484926 (1995, 1996 both to Agouron). Physical properties: M. Longer et al., J. Pharm. Sci. 84, 1090 (1995). HIV protease inhibition and antiviral activity: A. K. Patick et al., Antimicrob. Agents Chemother. 40, 292 (1996). Preclinical pharmacokinetics and tissue distribution: B. V. Shetty et al., ibid. 110. Review of pharmacology and clinical efficacy in HIV infection: A. Bardsley-Elliot, G. L. Plosker et al., Drugs 59, 581-620 (2000).
Properties: White foam. [a]D -119.23° (c = 0.26 in methanol). pKa1 6.0; pKa2 11.06. Log P (octanol/water): 4.1. Practically insol in water.
pKa: pKa1 6.0; pKa2 11.06
Optical Rotation: [a]D -119.23° (c = 0.26 in methanol)
Log P: Log P (octanol/water): 4.1
 
Derivative Type: Methanesulfonate
CAS Registry Number: 159989-65-8
Synonyms: Nelfinavir mesylate
Manufacturers' Codes: AG-1343
Trademarks: Viracept (Agouron)
Molecular Formula: C32H45N3O4S.CH3SO3H
Molecular Weight: 663.89
Percent Composition: C 59.70%, H 7.44%, N 6.33%, O 16.87%, S 9.66%
Properties: White powder. pKa -1.20. Soly (mg/ml): 4.5 in water; 2.6 in 0.1N HCl. Soly (mg/g): 70 in glycerin; >100 in propylene glycol; >200 in PEG 400. Very sol in methanol, ethanol, acetonitrile. Practically insol in soybean oil, mineral oil.
pKa: pKa -1.20
 
Therap-Cat: Antiviral.
Keywords: Antiviral; Peptidomimetics; HIV Protease Inhibitor.