Home > Name List By other > [2,6-di(propan-2-yl)phenyl] N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate

CAS No 166518-60-1 , [2,6-di(propan-2-yl)phenyl]
N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate

  • Name: [2,6-di(propan-2-yl)phenyl]
    N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate
  • Synonyms: CI-1011;166518-60-1; Avasimibe; 2,6-diisopropylphenyl[(2,4,6-triisopropylphenyl)acetyl]sulfamate;[2,6-di(propan-2-yl)phenyl]
    N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate; Avasimibe(CI-1011);
  • CAS Registry Number:
  • Density: 1.072 g/cm3
  • Refractive index: 1.529
  • Molecular Weight: 501.72102
  • InchiKey: PTQXTEKSNBVPQJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28
    (31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,
    16H2,1-10H3,(H,30,31)
  • Molecular Formula: C29H43NO4S
  • Molecular Structure:CAS No:166518-60-1 [2,6-di(propan-2-yl)phenyl]<br />N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate

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References of [2,6-di(propan-2-yl)phenyl]
N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate
Title: Avasimibe
CAS Registry Number: 166518-60-1
CAS Name: [[2,4,6-Tris(1-methylethyl)phenyl]acetyl]sulfamic acid 2,6-bis(1-methylethyl)phenyl ester
Synonyms: 2,6-diisopropylphenyl[(2,4,6-triisopropylphenyl)acetyl]sulfamate
Manufacturers' Codes: CI-1011; PD-148515
Molecular Formula: C29H43NO4S
Molecular Weight: 501.72
Percent Composition: C 69.42%, H 8.64%, N 2.79%, O 12.76%, S 6.39%
Literature References: Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor. Prepn: H. T. Lee et al., WO 9426702; eidem, US 5491172 (1994, 1996 both to Warner Lambert). Scale up synthesis: G. J. Dozeman et al, Org. Process Res. Dev. 1, 137 (1997). ACAT inhibition studies: H. T. Lee et al., J. Med. Chem. 39, 5031 (1996). HPLC/MS/MS determn in plasma: W. W. Bullen et al., J. Pharm. Biomed. Anal. 17, 1399 (1998). Clinical evaluation in hyperlipidemia: W. Insull Jr. et al., Atherosclerosis 157, 137 (2001). Toxicology: D. G. Robertson et al., Toxicol. Sci. 59, 324 (2001). Reviews of development and therapeutic potential: R. Jones, Curr. Opin. Cardiovasc. Pulmon. Renal Invest. Drugs 1, 263-269 (1999); idem, ibid. 2, 274-278 (2000).
Properties: White solid, mp 178-180° (Lee). Also reported as white powder, mp 169.5-170.4° (Dozeman).
Melting point: mp 178-180° (Lee); mp 169.5-170.4° (Dozeman)
 
Derivative Type: Sodium salt
CAS Registry Number: 166518-61-2
Properties: White solid, mp 250-252°.
Melting point: mp 250-252°
 
Therap-Cat: Antilipemic.
Keywords: Antilipemic.