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CAS No 175481-36-4 , (2R)-2-acetamido-N-benzyl-3-methoxypropanamide

  • Name: (2R)-2-acetamido-N-benzyl-3-methoxypropanamide
  • Synonyms: (R)-2-acetamido-N-benzyl-3-methoxypropanamide; 175481-36-4; Harkoseride; Erlosamide;(2R)-2-acetamido-N-benzyl-3-methoxypropanamide; Vimpat;Lacosamide; SPM 927; Erlosamide [INN]; S1253_Selleck;
  • CAS Registry Number:
  • Flash Point: 278.2 °C
  • Boiling Point: 536.4 °Cat760mmHg
  • Density: 1.12 g/cm3
  • Refractive index: 1.52
  • Flash Point: 278.2 °C
  • Molecular Weight: 250.29362
  • InchiKey: VPPJLAIAVCUEMN-GFCCVEGCSA-N
  • InChI: InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-
    7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1
  • Molecular Formula: C13H18N2O3
  • Molecular Structure:CAS No:175481-36-4 (2R)-2-acetamido-N-benzyl-3-methoxypropanamide

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References of (2R)-2-acetamido-N-benzyl-3-methoxypropanamide
Title: Lacosamide
CAS Registry Number: 175481-36-4
CAS Name: (2R)-2-(Acetylamino)-3-methoxy-N-(phenylmethyl)propanamide
Synonyms: (R)-N-benzyl-2-acetamido-3-methoxypropionamide; erlosamide; harkoseride
Manufacturers' Codes: ADD-234037; SPM-927
Molecular Formula: C13H18N2O3
Molecular Weight: 250.29
Percent Composition: C 62.38%, H 7.25%, N 11.19%, O 19.18%
Literature References: Functionalized amino acid with demonstrated anticonvulsant and analgesic activity. Prepn: D. Choi et al., J. Med. Chem. 39, 1907 (1996); H. Kohn, WO 9733861; idem, US 5773475 (1997, 1998 both to Research Corp. Technol.). Improved prepn and anticonvulsant activity: S. V. Andurkar et al., Tetrahedron: Asymmetry 9, 3841 (1998). Mode of action study: G. Lees et al., Neuropharmacology 50, 98 (2006). Evaluation in animal models of seizure: G. E. Duncan, H. Kohn, Epilepsy Res. 67, 81 (2005); of inflammatory pain: T. St?hr et al., Eur. J. Pain 10, 241 (2006). Clinical evaluation in neuropathic pain: G. McCleane et al., Neurosci. Lett. 352, 117 (2003). Review of clinical development: C. A. Hovinga, IDrugs 6, 479-485 (2003).
Properties: White solid, mp 143-144°. [a]D23 +16.0° (c = 1 in CH3OH).
Melting point: mp 143-144°
Optical Rotation: [a]D23 +16.0° (c = 1 in CH3OH)
Therap-Cat: Analgesic; anticonvulsant.
Keywords: Analgesic (Non-Narcotic); Anticonvulsant.