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CAS No 198470-84-7 , n-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide

  • Name: n-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide
  • Synonyms: n-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide;N-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.264g/cm3
  • Refractive index: 1.58
  • Flash Point: °C
  • Molecular Weight: 0
  • InChI: InChI=1S/C19H20N2O4S/c1-3-18(22)20-26(23,24)17-11-9-15(10-12-17)19-14(2)25-13-21(19)16-7-5-4-6-8-16/h4-12H,3,13H2,1-2H3,(H,20,22)
  • Molecular Formula: C19H18N2O4S
  • Molecular Structure:CAS No:198470-84-7 n-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide

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References of n-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide
Title: Parecoxib
CAS Registry Number: 198470-84-7
CAS Name: N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide
Molecular Formula: C19H18N2O4S
Molecular Weight: 370.42
Percent Composition: C 61.61%, H 4.90%, N 7.56%, O 17.28%, S 8.66%
Literature References: Injectable prodrug of valdecoxib, q.v., a selective cyclooxygenase-2 (COX-2) inhibitor. Prepn: J. J. Talley et al., WO 9738986; eidem, US 5932598 (1997, 1999 both to Searle); eidem, J. Med. Chem. 43, 1661 (2000). Clinical pharmacokinetics: A. Karim et al., J. Clin. Pharmacol. 41, 1111 (2001). Pharmacological profile: S. S. V. Padi et al., Eur. J. Pharmacol. 491, 69 (2004). Clinical evaluation in post-surgical pain: N. A. Nussmeier et al., Anesthesiology 104, 518 (2006). Comparison of GI effects with ketorolac: R. R. Stoltz et al., Am. J. Gastroenterol. 97, 65 (2002). Review of pharmacology and clinical experience: S. M. Cheer, K. L. Goa, Drugs 61, 1133-1141 (2001).
Properties: mp 148.9-151°.
Melting point: mp 148.9-151°
 
Derivative Type: Sodium salt
CAS Registry Number: 198470-85-8
Manufacturers' Codes: SC-69124A
Trademarks: Dynastat (Pfizer)
Molecular Formula: C19H17N2NaO4S
Molecular Weight: 392.40
Percent Composition: C 58.16%, H 4.37%, N 7.14%, Na 5.86%, O 16.31%, S 8.17%
Properties: mp 271.5-272.7°.
Melting point: mp 271.5-272.7°
 
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Anti-inflammatory (Nonsteroidal); Analgesic (Non-Narcotic); Cyclooxygenase-2 Selective Inhibitor.