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CAS No 2001-95-8 , Valinomycin

  • Name: Valinomycin
  • Synonyms: Cyclo(D-a-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-a-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-a-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl);NSC 122023;1,7,13,19,25,31-Hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone,3,6,9,15,18,21,27,30,33-nonaisopropyl-12,24,36-trimethyl- (7CI); Valinomicin;1,7,13,19,25,31-Hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane, cyclicpeptide deriv.;Valinomycin;
  • CAS Registry Number:
  • Transport: UN 2811 6
  • Density: 1.060
  • Refractive index: 1.448
  • Safety Statements: Poison by ingestion, skin contact, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 217-896-6
  • Molecular Weight: 1111.32
  • InChI: InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)
  • Risk Statements: 27/28
  • Molecular Formula: C54H90N6O18
  • Molecular Structure:CAS No:2001-95-8 Valinomycin

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2001-95-8 VALINOMYCIN; CYCLO(D-A-HYDROXYISOVALERYL-D-VALYL-L-LACTOYL-L-VALYL-D-A-HYDROXYISOVALERYL-D-VALYL-L-LACTOYL-L-VALYL-D-A-HYDROXYISOVALERYL-D-VALYL-L-LACTOYL-L-VALYL)

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2001-95-8 VALINOMYCIN

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
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  • Address: Cfm Oskar Tropitzsch
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2001-95-8 VALINOMYCIN BIOCHEMICA

  • Germany AppliChem GmbH [Manufacturer]
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2001-95-8 SC-200991 VALINOMYCIN

  • United States Santa Cruz Biotechnology, Inc. [Manufacturer]
  • Tel: 831-457-3800/ 800-457-3801
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  • Address: Santa Cruz Biotechnology, Inc.
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2001-95-8 VALINOMYCIN

  • United States Cayman Chemical Company [Manufacturer]
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2001-95-8 3373 VALINOMYCIN

  • United States Tocris Bioscience [Manufacturer]
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2001-95-8 Valinomycin

  • United States Tocris Bioscience [Manufacturers]
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2001-95-8 Valinomycin

  • Israel Fermentek Ltd [Manufacturers]
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References of Valinomycin
Title: Valinomycin
CAS Registry Number: 2001-95-8
Molecular Formula: C54H90N6O18
Molecular Weight: 1111.32
Percent Composition: C 58.36%, H 8.16%, N 7.56%, O 25.91%
Literature References: Cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins, q.v. Composed of 3 moles each of L-valine, D-a-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring: Brockmann et al., Ber. 88, 57 (1955); Ann. 603, 216 (1957). Structural studies: Shemyakin et al., Tetrahedron Lett. 1963, 351; Tetrahedron 19, 995 (1963). Proposed structure: Brockmann et al., Naturwissenschaften 50, 689 (1963). Structure and synthesis: Shemyakin et al., Tetrahedron Lett. 1963, 1921. Solid phase synthesis: Gisin et al., J. Am. Chem. Soc. 91, 2691 (1969); Losse, Klengel, Tetrahedron 27, 1423 (1971). Biosynthesis: Smirnova et al., C.A. 73, 97347m (1970); Ristow et al., FEBS Lett. 42, 127 (1974). Conformation: Ivanov et al., Biochem. Biophys. Res. Commun. 34, 803 (1969); Onishi, Urry, ibid. 36, 194 (1969); Duax et al., Science 176, 911 (1972). Review: Y. A. Ovchinnokov, V. T. Ivanov, "The Cyclic Peptides: Structure, Conformation, and Function", in The Proteins vol. V, H. Neurath, R. L. Hill, Eds. (Academic Press, New York, 3rd ed., 1982) pp 563-573.
Properties: Shiny rectangular platelets from dibutyl ether, mp 190° (hot stage). [a]D20 +31.0° (c = 1.6 in benzene). Neutral reaction. Practically insol in water. Freely sol in petr ether, ether, benzene, chloroform, glacial acetic, butyl acetate, acetone. Active in vitro against Mycobacterium tuberculosis.
Melting point: mp 190° (hot stage)
Optical Rotation: [a]D20 +31.0° (c = 1.6 in benzene)
Use: Insecticide, nematocide, Patterson, Wright, US 3520973 (1970 to Am. Cyanamid).