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CAS No 204318-14-9 , DOTA-(Tyr3)-Octreotide

  • Name: DOTA-(Tyr3)-Octreotide
  • Synonyms: DOTA-(Tyr3)-Octreotide;
  • CAS Registry Number:
  • Flash Point: 996.2°C
  • Boiling Point: 1723.7°C at 760 mmHg
  • Density: 1.46g/cm3
  • Refractive index: 1.684
  • Flash Point: 996.2°C
  • Molecular Weight: 1421.639
  • InChI: InChI=1/C65H92N14O18S2/c1-39(81)51(36-80)72-64(96)53-38-99-98-37-52(73-60(92)48(28-41-10-4-3-5-11-41)68-54(84)32-76-20-22-77(33-55(85)86)24-26-79(35-57(89)90)27-25-78(23-21-76)34-56(87)88)63(95)70-49(29-42-15-17-44(83)18-16-42)61(93)71-50(30-43-31-67-46-13-7-6-12-45(43)46)62(94)69-47(14-8-9-19-66)59(91)75-58(40(2)82)65(97)74-53/h3-7,10-13,15-18,31,39-40,47-53,58,67,80-83H,8-9,14,19-30,32-38,66H2,1-2H3,(H,68,84)(H,69,94)(H,70,95)(H,71,93)(H,72,96)(H,73,92)(H,74,97)(H,75,91)(H,85,86)(H,87,88)(H,89,90)/t39-,40-,47+,48-,49+,50-,51-,52+,53+,58+/m1/s1
  • Molecular Formula: C65H92N14O18S2
  • Molecular Structure:CAS No:204318-14-9 DOTA-(Tyr3)-Octreotide

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204318-14-9 DOTA-(Tyr3)-Octreotide

  • DOTA-(Tyr3)-Octreotide
  • Switzerland Bachem [Manufacturer]
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204318-14-9 EDOTREOTIDUM

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References of DOTA-(Tyr3)-Octreotide
Title: Edotreotide
CAS Registry Number: 204318-14-9
CAS Name: N-[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic(2?7)-disulfide
Synonyms: (DOTA D-Phe1,Tyr3)octreotide; DOTATOC
Manufacturers' Codes: SMT-487
Molecular Formula: C65H92N14O18S2
Molecular Weight: 1421.64
Percent Composition: C 54.92%, H 6.52%, N 13.79%, O 20.26%, S 4.51%
Literature References: Octapeptide analog of somatostatin, q.v. Designed for targeted radiotherapy vs somatostatin receptor-expressing tumors. Prepn: R. Albert et al., EP 714911; eidem, US 6183721 (1996, 2001 both to Novartis); idem, et al., Bioorg. Med. Chem. Lett. 8, 1207 (1998). Solution-phase synthesis: M. Schottelius et al., Tetrahedron Lett. 44, 2393 (2003). In vivo antineoplastic activity: B. Stolz et al., Eur. J. Nucl. Med. 25, 668 (1998). Receptor binding study: J. C. Reubi et al., ibid. 27, 273 (2000). Clinical pharmacokinetics: F. Jamar et al., Eur. J. Nucl. Med. Mol. Imaging 30, 510 (2003). Clinical evaluation in neuroendocrine tumors: C. Waldherr et al., J. Nucl. Med. 43, 610 (2002).
Properties: Prepd as acetate. [a]22D -14.75° (c = 0.52 in 95% acetic acid).
Optical Rotation: [a]22D -14.75° (c = 0.52 in 95% acetic acid)
 
Derivative Type: 90Y chelate
CAS Registry Number: 322407-70-5
Manufacturers' Codes: 90Y-SMT-487
Trademarks: OctreoTher (Novartis)
 
Therap-Cat: 90Y chelate as antineoplastic.
Keywords: Somatostatin Analog.