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CAS No 206361-99-1 , [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl]
N-[(2S,
3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-
phenylbutan-2-yl]carbamate

  • Name: [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl]
    N-[(2S,
    3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-
    phenylbutan-2-yl]carbamate
  • Synonyms: TMC114;Prezista; 2ien; TMC 114; UIC-94017; TMC-114; 2idw;[(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl]
    N-[(2S,
    3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-
    phenylbutan-2-yl]carbamate; Darunavirum; Darunavirum [INN-Latin];
  • CAS Registry Number:
  • Density: 1.34g/cm3
  • Refractive index: 1.62
  • Molecular Weight: 547.66358
  • InchiKey: CJBJHOAVZSMMDJ-HEXNFIEUSA-N
  • InChI: InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,
    34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-
    17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,
    32)/t22-,23-,24+,25-,26+/m0/s1
  • Molecular Formula: C27H37N3O7S
  • Molecular Structure:CAS No:206361-99-1 [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl]<br />N-[(2S,<br />3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-<br />phenylbutan-2-yl]carbamate
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206361-99-1 Darunavir

  • Darunavir is a second generation protease inhibitor that targets the HIV-1 protease. It demonstrates extremely potent activity against the infectivity and replication of various strains of HIV-1, including several that are resistant to first generati...
  • Min. Order: 10
  • United States BOC Sciences [Manufacturer]
  • Tel: 1-631-6197922
  • Fax: 1-631-6147828
  • Address: 45-16 Ramsey Road Shirley New York,New YorkUnited States
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206361-99-1 Darunavir Ethanolate

  • Darunavir Ethanolate Darunavir ethanolate;Prezista, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3R,3aS,6aR)-hexahydrofuro(2,3-b)furan-3-yl ester, compd. with ethanol (1:1) cf:C27H37N3O7S·C2H6O fw:5...
  • China bolonpharm [Manufacturer]
  • Tel: 86-576-88702853
  • Fax: --
  • Address: Jiangkou Economic Development Zone,Huangyan, Taizhou, Zhejiang, China Taizhou,ZhejiangChina
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206361-99-1 Darunavir Ethanolate

  • Darunavir Ethanolate cf C27H37N3O7S·C2H6O fw:593.7377
  • China Taizhou Bolon Pharmchem CO.,Ltd [Manufacturer]
  • Tel: 86-576-88702853
  • Address: Huangyan Jiangkou taizhou,ZhejiangChina
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206361-99-1 DARUNAVIR

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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206361-99-1 Darunavir206361-99-1

  • Product Name: Darunavir Synonyms: [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester;Darunavir;TMC-114;UIC-94017;[(1S,2R)-3-[[(4-Aminophenyl)...
  • China Taizhou Bolon Pharmachem Co.,Ltd./Bolon Pharm&Chem Co.,Ltd [Manufacturer, Trading Company]
  • Tel: 86-576-88702850
  • Fax: --
  • Address: Jiangkou Economic Development Zone,Huangyan, Taizhou, Zhejiang, China taizhou city,ZhejiangChina
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206361-99-1 Darunavir

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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206361-99-1 Darunavir

  • Darunavir, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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206361-99-1 Darunavir

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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206361-99-1 Darunavir

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206361-99-1 Darunavir

  • China Boronsyn Co.,Ltd [Manufacturer]
  • Tel: +86-21-58407925
  • Fax: +86-21-58408291
  • Address: 1213 JunMin Road,Pudong,China ,China
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References of [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl]
N-[(2S,
3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-
phenylbutan-2-yl]carbamate
Title: Darunavir
CAS Registry Number: 206361-99-1
CAS Name: [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
Synonyms: (1S,2R,3¢R,3¢aS,6¢aR)-[3¢-hexahydrofuro[2,3-b]furanyl-[3-(4-aminobenzenesulfonyl)isobutylamino]-1-benzyl-2-hydroxypropyl]carbamate
Manufacturers' Codes: TMC-114; UIC-94017
Molecular Formula: C27H37N3O7S
Molecular Weight: 547.66
Percent Composition: C 59.21%, H 6.81%, N 7.67%, O 20.45%, S 5.85%
Literature References: Second generation HIV-1 protease inhibitor; structurally similar to amprenavir, q.v. Prepn: A. K. Ghosh et al., Bioorg. Med. Chem. Lett. 8, 687 (1998); idem et al., J. Org. Chem. 69, 7822 (2004). See also: J. W. Erickson, S. V. Gulnik, WO 9967417 (1999 to U.S. Dept. Health Human Serv.); J. W. Erickson et al., US 05158713 (2005 to Univ. Illinois). In vitro activity vs multidrug resistant HIV isolates: Y. Koh et al., Antimicrob. Agents Chemother. 47, 3123 (2003). Crystal structures of complex with protease variants: Y. Tie et al., J. Mol. Biol. 338, 341 (2004). Structure activity study and pharmacokinetic analysis: D. L. N. G. Surleraux et al., J. Med. Chem. 48, 1813 (2005). Review of pharmacology and clinical experience: A. C. Shurtleff, Curr. Opin. Invest. Drugs 5, 879-886 (2004). Clinical evaluation of combination with ritonavir: K. Arastéh et al., AIDS 19, 943 (2005).
Properties: White amorphous solid, mp 74° (dec).
Melting point: mp 74° (dec)
Therap-Cat: Antiviral.
Keywords: Antiviral; Peptidomimetics; HIV Protease Inhibitor.