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CAS No 212141-54-3 , N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

  • Name: N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
  • Synonyms: N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; Pynasunate; CGP-797870; 212141-54-3;N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; PTK/ZK; CGP 79787;Vatalanib base;
  • CAS Registry Number:
  • Melting Point: 209-212ºC
  • Density: 1.33 g/cm3
  • Refractive index: 1.711
  • Molecular Weight: 346.8129
  • InchiKey: YCOYDOIWSSHVCK-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-
    25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
  • Molecular Formula: C20H15ClN4
  • Molecular Structure:CAS No:212141-54-3 N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
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212141-54-3 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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212141-54-3 Vatalanib

  • Vatalanib, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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212141-54-3 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-

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212141-54-3 VATALANIB

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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212141-54-3 Vatalanib

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
  • Fax: +86-(21)-61094103
  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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212141-54-3 Vatalanib

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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212141-54-3 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-

  • China KINFON PHARMACEUTICAL AND CHEMICAL CO.LTD [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: +86-23-8650081
  • Fax: +86-23-8650081
  • Address: 7F,Commercial Building, No.3 Nanping West Road,Nan ,China
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212141-54-3 Vatalanib

  • Vatalanib(1) 1-Phtalazinamine,
  • India J.INC. [Manufacturer]
  • Tel: +91 79 30071152, 30071190, 30071175, 30071153
  • Fax: +91 79 30071176, 26574630
  • Address: # 95, Rangwala Towers, Law garden, Ellisbridge, Ahmedabad 380006, Gujarat State, India. 380006 AhmedabadINDIA Ahmedabad,India
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212141-54-3 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-

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212141-54-3 Vatalanib base

  • Vatalanib base
  • China Changzhou Huaren Chemical Co., Ltd [Manufacturer]
  • Tel: 86 519 812 2965
  • Fax: 86 519 810 4456
  • Address: 150 Heping South Road Changzhou, Jiangsu 213003 China ,China
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References of N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
Title: Vatalanib
CAS Registry Number: 212141-54-3
CAS Name: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
Synonyms: 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine
Manufacturers' Codes: CGP-79787
Molecular Formula: C20H15ClN4
Molecular Weight: 346.81
Percent Composition: C 69.26%, H 4.36%, Cl 10.22%, N 16.15%
Literature References: Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor; vascular endothelial angiogenesis inhibitor. Prepn: G. Bold et al., WO 9835958; eidem, US 6258812 (1998, 2001 both to Novartis); eidem, J. Med. Chem. 43, 2310 (2000). Enzyme inhibition study and pharmacology: J. M. Wood et al., Cancer Res. 60, 2178 (2000). Antiangiogenic activity: J. Drevs et al., ibid. 62, 4015 (2002). Clinical pharmacokinetics: B. Morgan et al., J. Clin. Oncol. 21, 3955 (2003). Review of mechanism of action: P. Furet, P. W. Manley ACS Symp. Ser. 796, 282-298 (2001); and therapeutic potential: A. L. Thomas et al., Semin. Oncol. 30, Suppl. 6, 32-38 (2003).
Properties: Crystals from water + diethyl ether, mp 209-212°.
Melting point: mp 209-212°
 
Derivative Type: Succinate
CAS Registry Number: 212142-18-2
Manufacturers' Codes: CGP-79787D; PTK-787; ZK-222584
Molecular Formula: C20H15ClN4.C4H6O4
Molecular Weight: 464.90
Percent Composition: C 62.00%, H 4.55%, Cl 7.63%, N 12.05%, O 13.77%
Properties: Crystals from ethanol, mp 195°.
Melting point: mp 195°
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Tyrosine Kinase Inhibitors.