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CAS No 220578-59-6 , ImmunoglobulinG4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 g4-chain)),disulfide with human-mouse monoclonal hP67.6 k-chain, dimer, methylN-[(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-a-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-a-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-b-D-ribo-hexopyranosyl]oxy]amino]-b-D-glucopyranosyl]oxy]-13-[2-[[3-[2-[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylidene]hydrazinyl]-1,1-di

  • Name: ImmunoglobulinG4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 g4-chain)),disulfide with human-mouse monoclonal hP67.6 k-chain, dimer, methylN-[(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-a-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-a-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-b-D-ribo-hexopyranosyl]oxy]amino]-b-D-glucopyranosyl]oxy]-13-[2-[[3-[2-[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylidene]hydrazinyl]-1,1-di
  • Synonyms: Mylotarg;Gemtuzumab zogamicin; WAY-CMA 676;ImmunoglobulinG4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 g4-chain)),disulfide with human-mouse monoclonal hP67.6 k-chain, dimer, methylN-[(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-a-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-a-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-b-D-ribo-hexopyranosyl]oxy]amino]-b-D-glucopyranosyl]oxy]-13-[2-[[3-[2-[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylidene]hydrazinyl]-1,1-di; Gemtuzumab ozogamicin; CMA 676; Gemtuzumab;ImmunoglobulinG4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 g4-chain)),disulfide with human-mouse monoclonal hP67.6 k-chain, dimer,methyl [(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-a-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-a-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-b-D-ribo-hexopyranosyl]oxy]amino]-b-D-glucopyranosyl]oxy]-13-[2-[[3-[[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylidene]hydrazino]-1,1-dimethyl-3-oxopropyl]dithio]ethylidene]-1-hydroxy-11-oxobicyclo[7.3.1]trideca-4,9-diene-2,6-diyn-10-yl]carbamateconjugate (9CI); CDP 771;
  • CAS Registry Number:
  • Density: 1.44g/cm3
  • Refractive index: 1.681
  • Molecular Weight: 1209.3983
  • InChI: InChI=1/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)
  • Molecular Formula: C59H84N16O12
  • Molecular Structure:CAS No:220578-59-6 ImmunoglobulinG4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 g4-chain)),disulfide with human-mouse monoclonal hP67.6 k-chain, dimer, methylN-[(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-a-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-a-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-b-D-ribo-hexopyranosyl]oxy]amino]-b-D-glucopyranosyl]oxy]-13-[2-[[3-[2-[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylidene]hydrazinyl]-1,1-di

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220578-59-6 GEMTUZUMAB

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220578-59-6 GEMTUZUMAB OZOGAMICIN

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References of ImmunoglobulinG4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 g4-chain)),disulfide with human-mouse monoclonal hP67.6 k-chain, dimer, methylN-[(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-a-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-a-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-b-D-ribo-hexopyranosyl]oxy]amino]-b-D-glucopyranosyl]oxy]-13-[2-[[3-[2-[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylidene]hydrazinyl]-1,1-di
Title: Gemtuzumab Ozogamicin
CAS Registry Number: 220578-59-6
Manufacturers' Codes: CDP-771; CMA-676
Trademarks: Mylotarg (Wyeth)
Literature References: Immunoconjugate of N-acetyl-g-calicheamicin with the humanized mouse monoclonal IgG4 k antibody, hP67.6, directed against the human CD33 antigen located on the surface of normal and leukemic myeloid cells, but not on normal hematopoietic stem cells. Designed to deliver antibody-targeted chemotherapy for treatment of acute myelocytic leukemia (AML). Prepn of conjugate: P. R. Hamann et al., EP 689845; eidem, US 5773001 (1996, 1998 both to Am. Cyanamid). In vitro antineoplastic activity: K. Naito et al., Leukemia 14, 1436 (2000). Clinical evaluation in AML: E. L. Sievers et al., Blood 93, 3678 (1999). Reviews of development and therapeutic potential: I. D. Bernstein, Leukemia 14, 474-475 (2000); I. Niculescu-Duvaz, Curr. Opin. Mol. Ther. 2, 691-696 (2000); of clinical experience: F. J. Giles, Expert Rev. Anticancer Ther. 2, 630-640 (2002).
Properties: Sensitive to light; protect from direct and indirect sunlight and unshielded fluorescent light.
Therap-Cat: Antineoplastic
Keywords: Antineoplastic; Monoclonal Antibodies.