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CAS No 22089-22-1 , N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2λ

  • Name: N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2λ
  • Synonyms: Trifosfamide; Trofosfamid;Trophosphamide; Trilofosfamida; Triphosphamide;5-oxazaphosphinan-2-amine; Ifosfamide mustard; Trisfosfamide; Ixoten; Trilophosphamide;N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2λ
  • CAS Registry Number:
  • Flash Point: 191.9°C
  • Boiling Point: 393.7°Cat760mmHg
  • Density: 1.35g/cm3
  • Refractive index: 1.518
  • Safety Statements: Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. Human systemic effects by unspecified routes: hematuria, leukopenia, and thrombocytopenia. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and POx.
  • Flash Point: 191.9°C
  • EINECS: 244-770-8
  • Molecular Weight: 323.584182
  • InchiKey: UMKFEPPTGMDVMI-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,
    15)14(7-3-11)8-4-12/h1-9H2
  • Molecular Formula: C9H18Cl3N2O2P
  • Molecular Structure:CAS No:22089-22-1 N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2λ

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22089-22-1 2H-1,3,2-Oxazaphosphorin-2-amine,N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide

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References of N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2λ
Title: Trofosfamide
CAS Registry Number: 22089-22-1
CAS Name: N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
Synonyms: 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide; N,N,N￠-tris(2-chloroethyl)-N￠,O-propylene phosphoric acid ester diamide; trilophosphamide; trophosphamide
Manufacturers' Codes: NSC-109723; Z-4828
Trademarks: Ixoten (Baxter)
Molecular Formula: C9H18Cl3N2O2P
Molecular Weight: 323.58
Percent Composition: C 33.41%, H 5.61%, Cl 32.87%, N 8.66%, O 9.89%, P 9.57%
Literature References: The 3-(2-chloroethyl) deriv of cyclophosphamide, q.v. Prepn: GB 1188159, C.A. 73, 44892d (1970); Arnold et al., DE 2107936, C.A. 77, 152238m (1972) (1970, 1972 both to Asta-Werke); K. Pankiewicz et al., J. Am. Chem. Soc. 101, 7712 (1979). Pharmacology: N. Brock, Int. Congr. Chemother., Proc. 5th, K. H. Spitzy, H. Haschek, Eds. (Verlag Wiener Med. Akad., Vienna, 1967) II(1), pp 155-161; J. Potel, N. Brock, Arzneim.-Forsch. 21, 1250 (1971); N. Brock, J. Potel, ibid. 24, 1149 (1974); Harrison, Fuquay, Proc. Soc. Exp. Biol. Med. 139, 957 (1972). Crystal and molecular structure: A. Perales, S. Garcia-Blanco, Acta Crystallogr. 33B, 1939 (1977).
Properties: Crystals from ether, mp 50-51°. [a]D25 -28.6° (c = 2 in CH3OH). LD50 i.p. in mice: 212 mg/kg (Brock, Potel).
Melting point: mp 50-51°
Optical Rotation: [a]D25 -28.6° (c = 2 in CH3OH)
Toxicity data: LD50 i.p. in mice: 212 mg/kg (Brock, Potel)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrogen Mustards.