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CAS No 22254-24-6 , Ipratropium bromide

  • Name: Ipratropium bromide
  • Synonyms: [(1R,5S)-8-Methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide;Ipratropium bromide;
  • CAS Registry Number:
  • Melting Point: 230-232 ºC
  • Safety Statements: S26
  • Hazard Symbols: Xn
  • EINECS: 244-873-8
  • Molecular Weight: 412.37
  • InChI: InChI=1/C20H30NO3.BrH/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H/q+1;/p-1/t16-,17?,18-,19?,21?;/m1./s1
  • Risk Statements: 20/22-36
  • Molecular Formula: C20H30BrNO3
  • Molecular Structure:CAS No:22254-24-6 Ipratropium bromide

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22254-24-6 Ipratropium Bromide

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22254-24-6 IPRATROPIUM BROMIDE

  • China Beijing Mediking Biopharm Co., Ltd [Manufacturer]
  • Tel: +86-10-81769620/ +86-10-81769521
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  • Address: Hongxianghong Incubator, Beiqijia Town,
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    Beijing China null,nullChina
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22254-24-6 Ipratropium bromide

  • China Zhejiang Myjoy Import & Export Co.,Ltd. [Importer/Exporter]
  • Tel: 86-571-28039808
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References of Ipratropium bromide
Title: Ipratropium Bromide
CAS Registry Number: 22254-24-6
CAS Name: (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide
Synonyms: 3a-hydroxy-8-isopropyl-1aH,5aH-tropanium bromide (±)-tropate; 8-isopropylnoratropine methobromide; N-isopropylnoratropinium bromomethylate
Manufacturers' Codes: Sch-1000
Trademarks: Atem (Chiesi); Atrovent (Boehringer, Ing.); Bitrop (Boehringer, Ing.); Itrop (Boehringer, Ing.); Narilet (Boehringer, Ing.); Respontin (GSK); Rinatec (Boehringer, Ing.)
Molecular Formula: C20H30BrNO3
Molecular Weight: 412.36
Percent Composition: C 58.25%, H 7.33%, Br 19.38%, N 3.40%, O 11.64%
Literature References: Anticholinergic. Prepn: K. Zeile et al., ZA 6707766; eidem, US 3505337 (1968, 1970, both to Boehringer, Ing.); W. Schulz et al., Arzneim.-Forsch. 26, 960 (1976). Chemistry and pharmacokinetics: W. Deckers, Postgrad. Med. J. 51, Suppl. 7, 76 (1975). Pharmacology and toxicology: A. Engelhardt, H. Klupp, ibid. 82. Series of articles on pharmacology, toxicology, pharmacokinetics and clinical studies: Arzneim.-Forsch. 26, 974-985, 989-1020 (1976). Toxicity data: L. Sarafana et al., ibid. 985. Review: R. Bauer et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 489-515. Symposium on pharmacology, toxicology and clinical efficacy: Am. J. Med. 81(5A), 1-102 (1986). Review of clinical toxicology: J. D. Truwit, Crit. Care Clin. 7, 639-657 (1991).
Properties: White crystals from n-propanol, mp 230-232°. Freely sol in water and lower alcohols. Insol in ether, chloroform and fluorohydrocarbons. Fairly stable in neutral and acid solns; rapidly hydrolyzed in alkaline soln. LD50 in male, female mice (mg/kg): 1001, 1083 orally; 12.29, 14.97 i.v.; 300, 340 s.c. LD50 in male, female rats (mg/kg): 1663, 1779 orally; 15.89, 15.70 i.v. (Sarafana).
Melting point: mp 230-232°
Toxicity data: LD50 in male, female mice (mg/kg): 1001, 1083 orally; 12.29, 14.97 i.v.; 300, 340 s.c.; LD50 in male, female rats (mg/kg): 1663, 1779 orally; 15.89, 15.70 i.v. (Sarafana)
Therap-Cat: Bronchodilator; antiarrhythmic.
Keywords: Antiarrhythmic; Antimuscarinic; Bronchodilator; Quaternary Ammonium Compounds.