Home > Name List By 1 > 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2, 3-benzodiazepine

CAS No 22345-47-7 , 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,
3-benzodiazepine

  • Name: 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,
    3-benzodiazepine
  • Synonyms: Tofisopamum [INN-Latin]; 22345-47-7; Tofisopam [INN:DCF:JAN]; Seriel;1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,
    3-benzodiazepine; tofizopam;Grandaxin; EINECS 244-922-3; Egyt 341;
  • CAS Registry Number:
  • Transport: UN 3077
  • Density: 1.15g/cm3
  • Refractive index: 1.558
  • Water Solubility: DMSO: ~14 mg/mL
  • Safety Statements: R22;R50
  • Hazard Symbols: Xn: Harmful;N: Dangerous for the environment;
  • EINECS: 244-922-3
  • Molecular Weight: 382.45284
  • InchiKey: RUJBDQSFYCKFAA-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)
    17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3
  • Risk Statements: S60;S61
  • Molecular Formula: C22H26N2O4
  • Molecular Structure:CAS No:22345-47-7 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,<br />3-benzodiazepine

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22345-47-7 1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-7,8-DIMETHOXY-4-METHYL-5H-2,3-BENZODIAZEPINE

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22345-47-7 TOFISOPAM

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References of 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,
3-benzodiazepine
Title: Tofisopam
CAS Registry Number: 22345-47-7
CAS Name: 1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
Manufacturers' Codes: EGYT-341
Trademarks: Grandaxin (EGYT); Seriel (Biogalenique)
Molecular Formula: C22H26N2O4
Molecular Weight: 382.45
Percent Composition: C 69.09%, H 6.85%, N 7.32%, O 16.73%
Literature References: The first 5H-2,3-benzodiazepine. Prepn: J. Korosi et al., HU 155572 (1969 to Pharm. Res. Inst.), C.A. 70, 115026a (1969); GB 1202579 corresp to US 3736315 (1970, 1973 both to EGYT); J. Korosi, T. Lang, Ber. 107, 3883 (1974). Synthesis and conformation: eidem, Ther. Hung. 23, 132 (1975). FT 13C NMR study: A. Neszmelyi et al., Ber. 107, 3894 (1974). Pharmacology: L. Petocz, I. Kosoczky, Ther. Hung. 23, 134 (1975). Human pharmacokinetics: S. Ronai et al., ibid. 139. Comparative efficacy: H. L. Goldberg, R. J. Finnerty, Am. J. Psychiatry 136, 196 (1979).
Properties: Colorless to light cream cryst powder from isopropyl alcohol, mp 156-157°. uv max (methanol): 310, 272, 239 nm (e 16100, 11200, 26300).
Melting point: mp 156-157°
Absorption maximum: uv max (methanol): 310, 272, 239 nm (e 16100, 11200, 26300)
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.