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CAS No 22668-01-5 , N-(2-hydroxyethyl)-2-(2-nitroimidazol-1-yl)acetamide

  • Name: N-(2-hydroxyethyl)-2-(2-nitroimidazol-1-yl)acetamide
  • Synonyms: Radinyl; Ethanidazole; 1H-Imidazole-1-acetamide; SR-2508;N-(2-hydroxyethyl)-2-(2-nitroimidazol-1-yl)acetamide; NSC-301467; Etanidazolum; Etanidazol; N-(2-hydroxyethyl)-2-nitro-;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.56g/cm3
  • Refractive index: 1.645
  • Safety Statements: Moderately toxic by intravenous and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: °C
  • Molecular Weight: 214.1787
  • InchiKey: WCDWBPCFGJXFJZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H10N4O4/c12-4-2-8-6(13)5-10-3-1-9-7(10)11(14)15/h1,3,12H,2,
    4-5H2,(H,8,13)
  • Risk Statements: 36/37/38
  • Molecular Formula: C7H10N4O4
  • Molecular Structure:CAS No:22668-01-5 N-(2-hydroxyethyl)-2-(2-nitroimidazol-1-yl)acetamide

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References of N-(2-hydroxyethyl)-2-(2-nitroimidazol-1-yl)acetamide
Title: Etanidazole
CAS Registry Number: 22668-01-5
CAS Name: N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide
Manufacturers' Codes: DUP-453; NSC-301467; SR-2508
Trademarks: Radinyl (Roberts)
Molecular Formula: C7H10N4O4
Molecular Weight: 214.18
Percent Composition: C 39.25%, H 4.71%, N 26.16%, O 29.88%
Literature References: Oxygen-mimetic which renders hypoxic cells sensitive to chemo- and radiotherapy. Prepn: A. G. Beaman et al., Antimicrob. Agents Chemother. 1967, 520. See also: W. W. Lee et al., US 4371540 (1983 to U.S. Sec'y Health Human Serv.). Pharmacology: J. M. Brown et al., Int. J. Radiat. Oncol. Biol. Phys. 7, 695 (1981). HPLC determn in biological materials: R. Ward, P. Workman, J. Chromatogr. 420, 223 (1987). Clinical pharmacokinetics and efficacy in radiation therapy: T. H. Wasserman et al., Radiother. Oncol. 20, Suppl. 1, 129 (1991). Evaluation in combination with alkylating agents: L. N. Shulman et al., Int. J. Radiat. Oncol. Biol. Phys. 29, 545 (1994).
Properties: Crystals from ethanol, mp 162-163° (Beaman); also reported as white powder from ethyl acetate + methanol, mp 164.5-165° (Lee). Partition coefficient (octanol/water): 0.046. uv max (isopropanol): 313 nm (e 7800). Soly in isotonic saline: 200 mg/ml.
Melting point: mp 162-163° (Beaman); mp 164.5-165° (Lee)
Log P: Partition coefficient (octanol/water): 0.046
Absorption maximum: uv max (isopropanol): 313 nm (e 7800)
Therap-Cat: Antineoplastic adjunct (radiosensitizer).
Keywords: Antineoplastic Adjunct; Radiosensitizer.