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CAS No 242478-37-1 , Solifenacin

  • Name: Solifenacin
  • Synonyms: Solifenacin; Solifenacin intermediate;[(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate;
  • CAS Registry Number:
  • Flash Point: 259.5°C
  • Boiling Point: 505.5°C at 760 mmHg
  • Density: 1.24g/cm3
  • Refractive index: 1.648
  • Flash Point: 259.5°C
  • Molecular Weight: 362.47
  • InChI: InChI=1/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21?,22-/m0/s1
  • Molecular Formula: C23H26N2O2
  • Molecular Structure:CAS No:242478-37-1 Solifenacin

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242478-37-1 Solifenacin

  • China YiPeng Chemical [Manufacturers]
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242478-37-1 SOLIFENACIN-13C6 SUCCINATE

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References of Solifenacin
Title: Solifenacin
CAS Registry Number: 242478-37-1
CAS Name: (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester
Synonyms: (1S,3￠R)-3￠quinuclidinyl-1-phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate
Molecular Formula: C23H26N2O2
Molecular Weight: 362.46
Percent Composition: C 76.21%, H 7.23%, N 7.73%, O 8.83%
Literature References: Muscarinic M3 receptor antagoinst. Prepn: M. Takeuchi et al., WO 9620194; eidem, US 6017927 (1996, 2000 both to Yamanouchi). Receptor binding studies: K. Ikeda et al., Arch. Pharmacol. 366, 97 (2002); selectivity profile: A. Ohtake et al., Eur. J. Pharmacol. 492, 243 (2004). Clinical study in overactive bladder: C. R. Chapple et al., Br. J. Urol. 93, 303 (2004); F. Habb et al., Eur. Urol. 47, 376 (2005). Clinical comparison with tolterodine: C. R. Chapple et al., ibid. 48, 464 (2005). Review of efficacy and tolerability studies: S. Brunton, L. Kuritzky, Curr. Med. Res. Opin. 21, 71-80 (2005); of clinical development: C. K. Payne, Drugs 66, 175-190 (2006).
Properties: Yellow oil.
 
Derivative Type: Succinate
CAS Registry Number: 242478-38-2
Manufacturers' Codes: YM-905
Trademarks: Vesicare (Yamanouchi)
Molecular Formula: C23H26N2O2.C4H6O4
Molecular Weight: 480.55
Percent Composition: C 67.48%, H 6.71%, N 5.83%, O 19.98%
Properties: White to slightly yellowish crystals, mp ~145°. Freely sol in acetic acid, water, methanol, dimethylsulfoxide.
Melting point: mp ~145°
 
Therap-Cat: In treatment of urinary incontinence.
Keywords: Antimuscarinic.