Home > Name List By other > (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11, 17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15, 16-octahy...

CAS No 25122-41-2 , (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,
17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,
16-octahydrocyclopenta[a]phenanthren-3-one

  • Name: (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,
    17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,
    16-octahydrocyclopenta[a]phenanthren-3-one
  • Synonyms: Clobetasol [INN:BAN];Clobetasolum; 25122-41-2; 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione;(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,
    17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,
    16-octahydrocyclopenta[a]phenanthren-3-one;
  • CAS Registry Number:
  • Transport: HAZARD
  • Melting Point: 195 - 197C (decomposes)
  • Density: 1.32 g/cm3
  • Refractive index: 1.582
  • EINECS: 246-633-8
  • Molecular Weight: 410.906723
  • InchiKey: FCSHDIVRCWTZOX-DVTGEIKXSA-N
  • InChI: InChI=1S/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,
    24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,
    10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
  • Molecular Formula: C22H28ClFO4
  • Molecular Structure:CAS No:25122-41-2 (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,<br />17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,<br />16-octahydrocyclopenta[a]phenanthren-3-one

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References of (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,
17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,
16-octahydrocyclopenta[a]phenanthren-3-one
Title: Clobetasol
CAS Registry Number: 25122-41-2
CAS Name: (11b,16b)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Molecular Formula: C22H28ClFO4
Molecular Weight: 410.91
Percent Composition: C 64.30%, H 6.87%, Cl 8.63%, F 4.62%, O 15.57%
Literature References: Topical corticosteroid. Prepn: Elks et al., DE 1902340; eidem, US 3721687 (1969, 1973 both to Glaxo). Review of pharmacology and clinical efficacy in skin disorders: E. A. Olsen, R. C. Cornell, J. Am. Acad. Dermatol. 15, 246-255 (1986).
 
Derivative Type: 17-Propionate
CAS Registry Number: 25122-46-7
Manufacturers' Codes: GR-2/925
Trademarks: Clobesol (GSK); Dermovate (GSK); Olux (Connetics); Psorex (GSK); Temovate (GSK)
Molecular Formula: C25H32ClFO5
Molecular Weight: 466.97
Percent Composition: C 64.30%, H 6.91%, Cl 7.59%, F 4.07%, O 17.13%
Properties: White or almost white colorless, crystalline powder, mp 195.5-197°. [a]D +103.8° (c = 1.04 in dioxane). uv max (ethanol): 237 nm (e 15000). Insol in water.
Melting point: mp 195.5-197°
Optical Rotation: [a]D +103.8° (c = 1.04 in dioxane)
Absorption maximum: uv max (ethanol): 237 nm (e 15000)
 
Therap-Cat: Glucocorticoid; anti-inflammatory.
Keywords: Glucocorticoid.