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CAS No 25717-80-0 , (1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate

  • Name: (1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate
  • Synonyms: SIN-10;Corvaton; Motazomin;(1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate; Sydnopharm; Molsidominum [INN-Latin]; Morial; Molsidolat; morsydomine; 25717-80-0;
  • CAS Registry Number:
  • Melting Point: 140-141 ºC
  • Safety Statements: 36
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 247-207-4
  • Molecular Weight: 242.23186
  • InchiKey: XLFWDASMENKTKL-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,
    2-6H2,1H3
  • Risk Statements: 22
  • Molecular Formula: C9H14N4O4
  • Molecular Structure:CAS No:25717-80-0 (1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate
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25717-80-0 molsidomine

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25717-80-0 molsidomine

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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25717-80-0 Molsidomine

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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25717-80-0 Molsidomine

  • Molsidomine B140250 25717-80-0
  • China bepharm ltd. []
  • Tel: 86-21-51816456
  • Address: 128 Xiangyin Road, Room C320-321 Yangpu District, Shanghai 200433, China ,China
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25717-80-0 Molsidomine

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25717-80-0 MOLSIDOMINE

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany ,Germany
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25717-80-0 MOLSIDOMINE

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland ,Switzerland
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25717-80-0 Molsidomine

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25717-80-0 molsidomine

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25717-80-0 Molsidomine

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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References of (1E)-1-ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate
Title: Molsidomine
CAS Registry Number: 25717-80-0
CAS Name: N-(Ethoxycarbonyl)-3-(4-morpholinyl)sydnone imine
Synonyms: N-carboxy-3-morpholinosydnonimine ethyl ester; morsydomine
Manufacturers' Codes: SIN-10
Trademarks: Corvaton (Aventis); Corvasal (Aventis); Molsidolat (Aventis); Morial (Takeda); Motazomin (Takeda)
Molecular Formula: C9H14N4O4
Molecular Weight: 242.23
Percent Composition: C 44.63%, H 5.83%, N 23.13%, O 26.42%
Literature References: Coronary vasodilator; member of a class of non-benzene aromatic, heterocyclic and mesoionic type of compounds previously unknown in the pharmaceutical industry. Developmental work on sydnone imines: Brookes, Walker, J. Chem. Soc. 1957, 4409. Prepn: K. Masuda et al., JP 70 6265; eidem, US 3769283 (1970, 1973 both to Takeda); eidem, Chem. Pharm. Bull. 19, 72 (1971). Stability studies: Asahi et al., ibid. 19, 1079 (1971). Pharmacological studies: Kikuchi et al., Jpn. J. Pharmacol. 20, 102, 187, 253 (1970); Hashimoto et al., Arzneim.-Forsch. 21, 1329 (1971); T. Nakaguchi et al., Toho Igakkai Zasshi 17, 26 (1970). Metabolism: S. Tanayama et al., Xenobiotica 4, 175 (1974). Pharmacokinetics: R. Bergstrand et al., Eur. J. Clin. Pharmacol. 27, 203 (1984). Clinical trial in angina pectoris: P. A. Majid et al., N. Engl. J. Med. 302, 1 (1980); in hypertension: J. Melei et al., Eur. J. Clin. Pharmacol. 18, 231 (1980). Synergism with penbutolol in angina pectoris: A. E. Balestrini et al., ibid. 27, 1 (1984). Review of pharmacology: R.-E. Nitz, V. B. Fiedler, Pharmacotherapy 7, 28 (1987). Review: Jpn. Med. Gaz. 8(9), 10 (1971); E. Bassenge, W. R. Kukovetz in New Drugs Annual: Cardiovascular Drugs Vol. 2, A. Scriabine, Ed. (Raven Press, New York, 1984) pp 177-191.
Properties: Colorless crystals or white cryst powder, practically tasteless and odorless, mp 140-141° (toluene). Freely sol in CHCl3. Sol in dil HCl, ethanol, ethyl acetate, methanol; sparingly sol in water, acetone, benzene. Very slightly sol in ether, petr ether. pK (100°) 3.0 ± 0.1. Most stable in aq solns pH 5-7; least stable in very alkaline solns. uv max (CHCl3): 326 nm. Sensitive to light of l <320 mm. LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi).
Melting point: mp 140-141° (toluene)
pKa: pK (100°) 3.0 ± 0.1
Absorption maximum: uv max (CHCl3): 326 nm
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi)
Therap-Cat: Antianginal.
Keywords: Antianginal.