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CAS No 26844-12-2 , N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide

  • Name: N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide
  • Synonyms: BRN 0494035;Indoramine; Wy-21901; Indoraminum [INN-Latin];N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide; 26844-12-2; EINECS 248-041-5; Indoramine [INN-French]; Indoramina [INN-Spanish];
  • CAS Registry Number:
  • Flash Point: 316.7°C
  • Boiling Point: 600°Cat760mmHg
  • Density: 1.21g/cm3
  • Refractive index: 1.657
  • Flash Point: 316.7°C
  • EINECS: 248-041-5
  • Molecular Weight: 347.4534
  • InchiKey: JXZZEXZZKAWDSP-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-
    18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)
  • Molecular Formula: C22H25N3O
  • Molecular Structure:CAS No:26844-12-2 N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide

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26844-12-2 INDORAMIN

  • United States 2A PharmaChem USA [Manufacturer]
  • Tel: 630-322-8887
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  • Address: 2A PharmaChem USA
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26844-12-2 INDORAMIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide
Title: Indoramin
CAS Registry Number: 26844-12-2
CAS Name: N-[1-[2-(1H-Indol-3-yl)ethyl]-4-piperidinyl]benzamide
Synonyms: 3-[2-(4-benzamidopiperidino)ethyl]indole
Manufacturers' Codes: Wy-21901
Molecular Formula: C22H25N3O
Molecular Weight: 347.45
Percent Composition: C 76.05%, H 7.25%, N 12.09%, O 4.60%
Literature References: a1-Adrenergic blocking agent with antihypertensive and bronchodilating activity. Prepn: J. L. Archibald, J. L. Jackson, ZA 6803204; eidem, US 3527761 (1969, 1970 both to Wyeth); J. L. Archibald et al., J. Med. Chem. 14, 1054 (1971). Pharmacological study: R. B. Royds et al., Clin. Pharmacol. Ther. 13, 380 (1972). Pharmacokinetics: G. H. Draffan et al., Br. J. Clin. Pharmacol. 3, 489 (1976). Antihypertensive activity: G. S. Stokes et al., Clin. Pharmacol. Ther. 25, 783 (1979). Cardiovascular effects in man: A. J. Coleman et al., J. Int. Med. Res. 7, 511 (1979). Effects on respiration in guinea pigs: C. Hamer, D. M. Temple, Agents Actions 10, 399 (1980). Determn of therapeutic concentrations: A. J. Swaisland, Analyst 106, 717 (1981). Symposium on pharmacology and clinical studies: Br. J. Clin. Pharmacol. 12, Suppl. 1, 1S-140S (1981). Review of pharmacology, therapeutic efficacy: B. Holmes, E. M. Sorkin, Drugs 31, 467-499 (1986).
Properties: Crystals from ethanol, mp 208-210°.
Melting point: mp 208-210°
 
Derivative Type: Hydrochloride
CAS Registry Number: 38821-52-2
Trademarks: Baratol (Wyeth); Doralese (GSK); Vidora (Wyeth); Wydora (Wyeth); Wypresin (Wyeth)
Molecular Formula: C22H25N3O.HCl
Molecular Weight: 383.91
Percent Composition: C 68.83%, H 6.83%, N 10.95%, O 4.17%, Cl 9.23%
Properties: Crystals, mp 230-232°. Recryst from isopropanol gives different cryst modification, mp 258-260°.
Melting point: mp 230-232°; mp 258-260°
 
Therap-Cat: Antihypertensive.
Keywords: a-Adrenergic Blocker; Antihypertensive.