Home > Name List By 6 > 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N, 4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine

CAS No 27469-53-0 , 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,
4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine

  • Name: 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,
    4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine
  • Synonyms: 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,
    4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine; Almitrinum [INN-Latin]; Almitrine dimesylate; Almitrine [INN:BAN]; Almitrine bismesylate;Almitrin; Vectarion; Almitrinum; Almitrina;
  • CAS Registry Number:
  • Density: 1.262 g/cm3
  • Refractive index: 1.633
  • Safety Statements: Poison by intraperitoneal and intravenous routes. When heated to decomposition it emits very toxic fumes of F− and NOx. See also ALLYL COMPOUNDS.
  • EINECS: 248-475-5
  • Molecular Weight: 477.552166
  • InchiKey: OBDOVFRMEYHSQB-UHFFFAOYSA-N
  • InChI: InChI=1S/C26H29F2N7/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-
    34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20/h3-12,23H,1-2,
    13-18H2,(H2,29,30,31,32,33)
  • Molecular Formula: C26H29F2N7
  • Molecular Structure:CAS No:27469-53-0 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,<br />4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine

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27469-53-0 Almitrine

  • China Yarong Chemical Development Ltd [Manufacturers]
  • Tel: +86-755-89707236
  • Fax: +86-755-89707211 +86-755-84507201
  • Address: Shenzhen,China Shenzhen,guanzghouChina
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References of 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,
4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine
Title: Almitrine
CAS Registry Number: 27469-53-0
CAS Name: 6-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]-N,N￠-di-2-propenyl-1,3,5-triazine-2,4-diamine
Synonyms: 2,4-bis[allylamino]-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine
Manufacturers' Codes: S-2620
Molecular Formula: C26H29F2N7
Molecular Weight: 477.55
Percent Composition: C 65.39%, H 6.12%, F 7.96%, N 20.53%
Literature References: Prepn: G. Regnier, R. Canevari, DE 1947332; eidem, US 3647794 (1970, 1972 both to Sci. Union et Cie.-Soc. Fran?. Recher. Méd.). Physical properties and toxicity: G. Regnier et al., Experientia 28, 814 (1972). Pharmacology: M. Laubie, F. Diot, J. Pharmacol. 3, 363 (1972); M. Laubie, H. Schmitt, Eur. J. Pharmacol. 61, 125 (1980). Evaluation of combination with raubasine, q.v., in cerebral ischemia in rats: M. G. Borzeix, J. Cahn, Arzneim.-Forsch. 37, 491 (1987). Clinical effect on hypoxemia in chronic obstructive pulmonary disease: R. C. Bell et al., Ann. Intern. Med. 105, 342 (1986); B. Gothe et al., Am. J. Med. 84, 436 (1988).
Properties: Crystals, mp 181°.
Melting point: mp 181°
 
Derivative Type: Dimethanesulfonate
CAS Registry Number: 29608-49-9
Synonyms: Almitrine dimesylate
Trademarks: Vectarion (Servier)
Molecular Formula: C26H29F2N7.2CH3SO3H
Molecular Weight: 669.76
Percent Composition: C 50.21%, H 5.57%, F 5.67%, N 14.64%, S 9.58%, O 14.33%
Properties: mp 243° (dec). uv max (ethanol): 227, 246 nm (log e 4.52, 4.53). LD50 in mice: 210 mg/kg i.v., 390 mg/kg i.p., >2 g/kg orally (Regnier).
Melting point: mp 243° (dec)
Absorption maximum: uv max (ethanol): 227, 246 nm (log e 4.52, 4.53)
Toxicity data: LD50 in mice: 210 mg/kg i.v., 390 mg/kg i.p., >2 g/kg orally (Regnier)
 
Therap-Cat: Respiratory stimulant.
Keywords: Respiratory Stimulant.