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CAS No 28380-24-7 , Nigericin

  • Name: Nigericin
  • Synonyms: Antibiotic K 178; Antibiotic X 464; Stereoisomer oftetrahydro-6-[[9-methoxy-2,4,10-trimethyl-2-[octahydro-2,3'-dimethyl-5'-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-1,6-dioxaspiro[4.5]dec-7-yl]methyl]-a,3-dimethyl-2H-pyran-2-aceticacid; X 464;Azalomycin M; Antibiotic M 2;1,6-Dioxaspiro[4.5]decane,nigericin deriv.; Helixin C; Polyetherin A;Nigericin;
  • CAS Registry Number:
  • Transport: UN 3462 6
  • Melting Point: 245-255ºC
  • Flash Point: 226.9°C
  • Boiling Point: 779.9°Cat760mmHg
  • Density: 1.19g/cm3
  • Refractive index: 1.543
  • Water Solubility: Soluble in DMSO (50 mg/mL) and ethanol (20 mg/mL)
  • Safety Statements: 26-36/37/39-45
  • Hazard Symbols: T: Toxic;
  • Flash Point: 226.9°C
  • Molecular Weight: 746.94
  • InchiKey: DANUORFCFTYTSZ-SJSJOXFOSA-N
  • InChI: InChI=1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34/h21-35,41,44H,11-20H2,1-10H3,(H,42,43)/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+/m0/s1
  • Risk Statements: 25-36/37/38
  • Molecular Formula: C40H67NaO11
  • Molecular Structure:CAS No:28380-24-7 Nigericin
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28380-24-7 NIGERICIN

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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28380-24-7 SC-201518 NIGERICINNA

  • United States Santa Cruz Biotechnology, Inc. [Manufacturer]
  • Tel: 831-457-3800/ 800-457-3801
  • Fax: 831-457-3801
  • Address: Santa Cruz Biotechnology, Inc.
    2145 Delaware Ave.
    Santa Cruz, CA 95060 ,United States
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28380-24-7 NIGERICIN

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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28380-24-7 ZINC PICOLINATE

  • United States Graham Chemical Corporation [Manufacturer]
  • Tel: 847-304-4400
  • Fax: 847-304-8752
  • Address: 1250 South Grove Avenue
    Suite 206
    Barrington, Illinois 60010 ,United States
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28380-24-7 ZINC PICOLINATE

  • United States AerChem inc. [Manufacturer]
  • Tel: 800.523.0091/ 812.334.9996
  • Fax: 812.334.1960
  • Address: AerChem inc.
    3935 W Roll Avenue
    Bloomington IN 47403 ,United States
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28380-24-7 Nigericin

  • China Wuhan best co., Ltd [Manufacturers]
  • Tel: 15002783060
  • Fax: 15002783060
  • Address: zhongshan road wuhan,hubeiChina
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28380-24-7 Nigericin

  • China Fujian Kerui Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: 0086-591-83470739 83476798
  • Fax: 0086-591-3470739 3441193 5561960
  • Address: No.25 Jinbu Road, Cangshan District, Fuzhou, Fujian, China Fuzhou,FujianChina
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28380-24-7 NIGERICIN SODIUM SALT

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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References of Nigericin
Title: Nigericin
CAS Registry Number: 28380-24-7
Synonyms: Antibiotic K 178; antibiotic X-464; azalomycin M; helixin C; polyetherin A
Molecular Formula: C40H68O11
Molecular Weight: 724.96
Percent Composition: C 66.27%, H 9.45%, O 24.28%
Literature References: Polyether antibiotic which affects ion transport and ATPase activity in mitochondria; produced by Streptomyces hygroscopicus E-749 and structurally related to monensin, q.v. Isoln, characterization, production: R. L. Harned et al., Antibiot. Chemother. 1, 594 (1951); J. Berger et al., J. Am. Chem. Soc. 73, 5295 (1951); J. Shoji et al., J. Antibiot. 21, 402 (1968). Structure: L. K. Steinrauf et al., Biochem. Biophys. Res. Commun. 33, 29 (1968); T. Kubota et al., Chem. Commun. 1968, 1541; T. Kubota, S. Matsutani, J. Chem. Soc. C 1970, 695. Use in coccidiosis: M. Gorman, R. L. Hamill, US 3555150 (1971 to Lilly). Effect on calcium uptake and membrane potential in mitochondria: H. Rottenberg, A. Scarpa, Biochemistry 13, 4811 (1974). Stimulation of ATPase activity: H. Sze, Proc. Natl. Acad. Sci. USA 77, 5904 (1980). Approach to synthesis: C. P. Holmes, P. A. Bartlett, J. Org. Chem. 54, 98 (1989).
Properties: Colorless needles, mp 183.5-185°. [a]D24 +36.2° (c = 0.842 in CHCl3). Sol in alcohols, acetone, ethyl acetate, chloroform, benzene, ether; slightly sol in satd hydrocarbons. Practically insol in water. LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned).
Melting point: mp 183.5-185°
Optical Rotation: [a]D24 +36.2° (c = 0.842 in CHCl3)
Toxicity data: LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)
 
Derivative Type: Sodium salt
Molecular Formula: C40H67NaO11
Molecular Weight: 746.94
Percent Composition: C 64.32%, H 9.04%, Na 3.08%, O 23.56%
Properties: Crystals, mp 245-255° (dec). Sol in chloroform. Practically insol in water.
Melting point: mp 245-255° (dec)