Home > Name List By 4 > 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N- methylpyridine-2-carboxamide

CAS No 284461-73-0 , 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-
methylpyridine-2-carboxamide

  • Name: 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-
    methylpyridine-2-carboxamide
  • Synonyms: BAY-43-9006; Kinome_766; sorafenibum; CHEMBL1336; Sorafenib [INN];4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-
    methylpyridine-2-carboxamide;Nexavar; AC1L50CF; UNII-9ZOQ3TZI87; 284461-73-0;
  • CAS Registry Number:
  • Density: 1.454 g/cm3
  • Water Solubility: Soluble in DMSO; very poorly soluble in water
  • Molecular Weight: 464.82495
  • InchiKey: MLDQJTXFUGDVEO-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-
    14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,
    30)(H2,28,29,31)
  • Molecular Formula: C21H16ClF3N4O3
  • Molecular Structure:CAS No:284461-73-0 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-<br />methylpyridine-2-carboxamide
Search by region :

Select to

284461-73-0 Sorafenib

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
Contact Supplier

284461-73-0 Sorafenib

  • China XinChem Corporation [Manufacturers]
  • Tel: +86-(21)-34123252
  • Fax: +86-(21)-54153973
  • Address: 102/30, 3455 Chunshen Road, Shanghai 201100, null,ShanghaiChina
Contact Supplier

284461-73-0 Sorafenib

  • China Shanghai Hanhong Chemical Co., Ltd. [Manufacturer, Trading Company, Agent]
  • Tel: +86-(21)-64762736, 64531573
  • Fax: +86-(21)-54291107
  • Address: 206-209, NO.1 Building , NO.245,Jiachuan Road, Xuhui District, Shanghai, Xuhui District,ShanghaiChina
Contact Supplier

284461-73-0 Nexavar

  • Nexavar, 98%
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 null,nullChina
Contact Supplier

284461-73-0 Sorafenib tosylate

  • Sorafenib tosylate, 99,00%
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
Contact Supplier

284461-73-0 Sorafenib

  • China Shanghai Jinglan Chemical Co., Ltd. [Manufacturer]
  • Tel: 86-21-37789410
  • Fax: 86-21-64966973
  • Address: Room 513, 5th Floor, Building B,
    No. 18, Lane 1305, Huajing Road,
    Shanghai, 200231, P.R. China null,nullChina
Contact Supplier

284461-73-0 Sorafenib Mesylate

  • Sorafenib Mesylate, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

284461-73-0 Sorafenib Tosylate

  • Sorafenib TosylateSorafenib Tosylate, 98%
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-023-67030808-8010
  • Fax: +86-023-67030809
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,nullChina
Contact Supplier

284461-73-0 Sorafenib tosylate

  • Sorafenib tosylate, 98%
  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
  • Tel: +86-21-64968086
  • Fax: +86-21-64968086
  • Address: Room 128, Building B, No. 8 Lane 1305, Huajing Road, Xuhui District, Shanghai, P.R. China 200000 Shanghai CHINA Shanghai,nullChina
Contact Supplier

284461-73-0 Sorafenib

  • China Xingcheng Chempharm Co., Ltd [Manufacturer]
  • Tel: +86-576-88525005/ +86-576-88886292
  • Fax: +86-576-88225056
  • Address: B Area, 10F, Yaoda Mansion, 289, Shifu Road, Taizhou, Zhejiang, China 318000 null,nullChina
Contact Supplier

Select to

References of 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-
methylpyridine-2-carboxamide
Title: Sorafenib
CAS Registry Number: 284461-73-0
CAS Name: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Synonyms: N-4-(Chloro-3-(trifluoromethyl)phenyl)-N-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
Manufacturers' Codes: Bay-43-9006
Molecular Formula: C21H16ClF3N4O3
Molecular Weight: 464.82
Percent Composition: C 54.26%, H 3.47%, Cl 7.63%, F 12.26%, N 12.05%, O 10.33%
Literature References: Multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Prepn: B. Riedl et al., WO 0041698 (2000 to Bayer); eidem, US 03139605 (2003); D. Bankston et al., Org. Process Res. Dev. 6, 777 (2002). Structure-activity study: U. R. Khire et al., Bioorg. Med. Chem. Lett. 14, 783 (2004). Characterization of kinase inhibition: S. M. Wilhelm et al., Cancer Res. 64, 7099 (2004). Mechanism of action study: D. J. Panka et al., Cancer Res. 66, 1611 (2006). LC determn in serum: S. Afify et al., J. Chromatogr. B 809, 99 (2004). Clinical pharmacokinetics: H. Richly et al., Int. J. Clin. Pharmacol. Ther. 41, 620 (2003). Analysis of clinical safety and efficacy: D. Strumberg et al., Eur. J. Cancer 42, 548 (2006). Clinical evaluation and brief review: H. DeGrendele, Clin. Colorectal Cancer 3, 16-18 (2003). Review of clinical development: B. I. Rini, Expert Opin. Pharmacother. 7, 453-461 (2006).
Properties: White solid, mp 205.6°.
Melting point: mp 205.6°
 
Derivative Type: Tosylate
CAS Registry Number: 475207-59-1
Trademarks: Nexavar (Bayer)
Molecular Formula: C21H16ClF3N4O3.C7H8O3S
Molecular Weight: 637.03
Percent Composition: C 52.79%, H 3.80%, Cl 5.57%, F 8.95%, N 8.80%, O 15.07%, S 5.03%
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Tyrosine Kinase Inhibitors.