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CAS No 302-22-7 , Chlormadinone acetate

  • Name: Chlormadinone acetate
  • Synonyms: 6-Chloro-delta(4,6)-pregnadiene-17a-ol-3,20-dionacetate;Chlormadinone acetate; 6-Chloro-delta6-dehydro-17a-acetoxyprogesterone;
  • CAS Registry Number:
  • Melting Point: 212 ºC
  • Flash Point: 172.5°C
  • Boiling Point: 512.5°Cat760mmHg
  • Density: 1.23g/cm3
  • Refractive index: 1.562
  • Safety Statements: R60;R61;R40;R48
  • Hazard Symbols: T: Toxic;
  • Flash Point: 172.5°C
  • EINECS: 206-118-0
  • Molecular Weight: 404.93
  • InChI: InChI=1/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,16-18H,5-10H2,1-4H3/t16?,17?,18?,21-,22+,23+/m1/s1
  • Risk Statements: S53;S22;S36/37/39;S45
  • Molecular Formula: C23H29ClO4
  • Molecular Structure:CAS No:302-22-7 Chlormadinone acetate

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References of Chlormadinone acetate
Title: Chlormadinone Acetate
CAS Registry Number: 302-22-7
CAS Name: 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione
Synonyms: 6-chloro-17-hydroxypregna-4,6-diene-3,20-dione acetate; 6-chloro-6-dehydro-17a-hydroxyprogesterone acetate; 6-chloro-6-dehydro-17a-acetoxyprogesterone; 17a-acetoxy-6-chloro-6,7-dehydroprogesterone
Trademarks: Chronosyn (Veterinaria); Cyclonorm (Streuli); Fertiletten (Chassot); Gestafortin (Merck KGaA); Lormin (Lilly); Luteran (Cassenne); Matrol; Normenon (Syntex); Menstridyl; Prostal (Teikoku Zoki); Traslan (Gramon)
Molecular Formula: C23H29ClO4
Molecular Weight: 404.93
Percent Composition: C 68.22%, H 7.22%, Cl 8.76%, O 15.80%
Literature References: Orally active progestogen with antiandrogenic activity; has been used in combinations as an oral contraceptive. Prepn: Brückner, DE 1075114 (1960 to E. Merck, AG); Brückner et al., Ber. 94, 1225 (1961); Sciaky, Gazz. Chim. Ital. 91, 545 (1961); GB 932153; H. J. Ringold, A. Bowers, US 3485852 (1963, 1969 both to Syntex). Endocrinological activities: D. M. Brennan, R. J. Kraay, Acta Endocrinol. 44, 367 (1963). Metabolism: S. Honma et al., Chem. Pharm. Bull. 25, 2019 (1977). Clinical evaluation in prostatic carcinoma: R. Nishimura, K. Shida, Prostate, Suppl. 1, 27 (1981); in benign prostatic hypertrophy: T. Usui et al., Acta Urol. Jpn. 27, 327 (1981), B.A. 73, 27225 (1982). Review of carcinogenicity studies: IARC Monographs 21, 365-375 (1979).
Properties: Crystals from methanol or ether, mp 212-214°. [a]D +6° (c = 1 in CHCl3). uv max: 283.5, 286 nm (e 23400, 22100).
Melting point: mp 212-214°
Optical Rotation: [a]D +6° (c = 1 in CHCl3)
Absorption maximum: uv max: 283.5, 286 nm (e 23400, 22100)
 
Derivative Type: Mixture with ethinyl estradiol
CAS Registry Number: 37301-55-6
Trademarks: Amenyl; Lutestral (Cassenne); Menova (Merck KGaA)
 
Derivative Type: Mixture with mestranol
CAS Registry Number: 8065-91-6
Trademarks: C-Quens; Gestamestrol (Hermal); Sequens
 
Therap-Cat: Progestogen; antineoplastic (hormonal).
Therap-Cat-Vet: Progestogen; estrus regulator.
Keywords: Antineoplastic (Hormonal); Progestogens; Progestogen.