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CAS No 30652-11-0 , 3-hydroxy-1,2-dimethylpyridin-4-one

  • Name: 3-hydroxy-1,2-dimethylpyridin-4-one
  • Synonyms: 1,2-Dimethyl-3-hydroxypyrid-4-one; Deferiprone (INN); CP20; 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone; APO-066;Ferriprox; 30652-11-0;3-hydroxy-1,2-dimethylpyridin-4-one;
  • CAS Registry Number:
  • Melting Point: 271-273 ºC
  • Density: 1.225 g/cm3
  • Refractive index: 1.564
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 212-783-8
  • Molecular Weight: 139.15186
  • InchiKey: TZXKOCQBRNJULO-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
  • Risk Statements: S26;S37/39
  • Molecular Formula: C7H9NO2
  • Molecular Structure:CAS No:30652-11-0 3-hydroxy-1,2-dimethylpyridin-4-one
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  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
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References of 3-hydroxy-1,2-dimethylpyridin-4-one
Title: Deferiprone
CAS Registry Number: 30652-11-0
CAS Name: 3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone
Synonyms: 1,2-dimethyl-3-hydroxypyrid-4-one; DMHP; L1
Manufacturers' Codes: CP-20
Trademarks: Kelfer (Cipla)
Molecular Formula: C7H9NO2
Molecular Weight: 139.15
Percent Composition: C 60.42%, H 6.52%, N 10.07%, O 23.00%
Literature References: Orally active chelator that promotes urinary iron excretion. Prepn: M. Yasue et al., Yakugaku Zasshi 90, 1222 (1970), C.A. 74, 23102b (1971); G. J. Kontoghiorghes et al., Arzneim.-Forsch. 37, 1099 (1987). Iron binding studies: idem, Inorg. Chim. Acta 135, 145 (1987). HPLC determn in serum and urine: B. Dresow et al., J. Anal. Chem. 352, 562 (1995). Clinical pharmacokinetics: F. N. Al-Refaie et al., Br. J. Haematol. 89, 403 (1995). Clinical studies in transfusional iron overload: idem et al., ibid. 91, 224 (1995); N. F. Olivieri et al., N. Engl. J. Med. 332, 918 (1995). Review of pharmacology and clinical experience: G. J. Kontoghiorghes, Ann. N.Y. Acad. Sci. 612, 339-350 (1990); F. N. Al-Refaie, A. V. Hoffbrand, Baill. Clin. Haematol. 7, 941-963 (1994); of toxicology: G. J. Kontoghiorghes, Toxicol. Lett. 80, 1-18 (1995).
Properties: Needles from water, mp 266-268° (Yasue); also reported as mp 263-266° (Kontoghiorghes et al., 1987). Very bitter taste. Soly at 37° (mg/ml): water ~20 (pH 7.4). pKa1 3.3, pKa2 9.7. uv max (phosphate buffer saline, pH 7.3): 460 nm (e 3600). Hydrophilic chelator; forms red colored complexes with iron. LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995).
Melting point: mp 266-268° (Yasue); mp 263-266° (Kontoghiorghes et al., 1987)
pKa: pKa1 3.3, pKa2 9.7
Absorption maximum: uv max (phosphate buffer saline, pH 7.3): 460 nm (e 3600)
Toxicity data: LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)
Therap-Cat: Chelating agent (iron and aluminum).
Keywords: Chelating Agent.